脉冲串逆行胃电刺激对犬固体胃排空及血浆激素的影响。
Effects of retrograde gastric electrical stimulation with pulse trains on gastric emptying of solids and plasma hormones in dogs.
作者信息
Song Geng-Qing, Hou Xiaohua, Sun Yan, Yang Bin, Qian Wei, Chen Jiande D Z
机构信息
Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1307 Luoyu Road, Wuhan, P.R. 430074, China.
出版信息
Am J Surg. 2007 Jul;194(1):122-7. doi: 10.1016/j.amjsurg.2006.12.036.
BACKGROUND
Retrograde gastric electrical stimulation (RGES) is proposed as a novel therapy for obesity. However, mechanisms of RGES are not fully investigated. The aim of this study was to investigate the effects of RGES with trains of pulses on gastric slow waves, gastric emptying of solids, and plasma concentrations of satiety-related peptides and glucose.
METHODS
Seven female beagle dogs implanted with 4 pairs of gastric electrodes on the gastric serosa were studied (control and RGES). Gastric emptying, gastric slow waves, and signs were recorded in each session. Plasma leptin, insulin, glucagons, and glucose were also measured.
RESULTS
RGES with pulse trains (a pulse width of 2 milliseconds) significantly decreased gastric emptying of solids and plasma insulin but has no effect on plasma leptin, glucagons, and glucose.
CONCLUSION
Acute gastric electrical stimulation with pulse trains is able to decrease gastric emptying of solids and plasma insulin but has no effects on plasma leptin, glucagons, and glucose.
背景
逆行性胃电刺激（RGES）被提议作为一种治疗肥胖症的新疗法。然而，RGES的机制尚未得到充分研究。本研究的目的是探讨脉冲序列的RGES对胃慢波、固体食物胃排空以及饱腹感相关肽和葡萄糖血浆浓度的影响。
方法
对7只在胃浆膜上植入4对胃电极的雌性比格犬进行研究（对照组和RGES组）。每次实验记录胃排空、胃慢波和体征。同时测量血浆瘦素、胰岛素、胰高血糖素和葡萄糖水平。
结果
脉冲序列（脉冲宽度为2毫秒）的RGES显著降低了固体食物的胃排空和血浆胰岛素水平，但对血浆瘦素、胰高血糖素和葡萄糖水平没有影响。
结论
脉冲序列的急性胃电刺激能够降低固体食物的胃排空和血浆胰岛素水平，但对血浆瘦素、胰高血糖素和葡萄糖水平没有影响。
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