Adeoye Bukola, Nakiyingi Lydia, Moreau Yvetane, Nankya Ethel, Olson Alex J, Zhang Mo, Jacobson Karen R, Gupta Amita, Manabe Yukari C, Hosseinipour Mina C, Kumwenda Johnstone, Sagar Manish
Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.
Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
iScience. 2023 Apr 10;26(5):106631. doi: 10.1016/j.isci.2023.106631. eCollection 2023 May 19.
(Mtb) is the most common infection among people with HIV (PWH). Mtb disease-associated inflammation could affect HIV-directed immune responses in PWH. We show that HIV antibodies are broader and more potent in PWH in the presence as compared to the absence of Mtb disease. With co-existing Mtb disease, the virus in PWH also encounters unique antibody selection pressure. The Mtb-linked HIV antibody enhancement associates with specific mediators important for B cell and antibody development. This Mtb humoral augmentation does not occur due to cross-reactivity, a generalized increase in all antibodies, or differences in duration or amount of antigen exposure. We speculate that the co-localization of Mtb and HIV in lymphatic tissues leads to the emergence of potent HIV antibodies. PWH's Mtb disease status has implications for the future use of HIV broadly neutralizing antibodies as prophylaxis or treatment and the induction of better humoral immunity.
结核分枝杆菌（Mtb）是艾滋病毒感染者（PWH）中最常见的感染源。与Mtb疾病相关的炎症可能会影响PWH针对艾滋病毒的免疫反应。我们发现，与无Mtb疾病的情况相比，存在Mtb疾病时，PWH体内的艾滋病毒抗体更广泛且更有效。在同时存在Mtb疾病的情况下，PWH体内的病毒还会面临独特的抗体选择压力。与Mtb相关的艾滋病毒抗体增强与对B细胞和抗体发育重要的特定介质有关。这种Mtb体液增强并非由于交叉反应、所有抗体的普遍增加或抗原暴露持续时间或量的差异所致。我们推测，Mtb和艾滋病毒在淋巴组织中的共定位导致了强效艾滋病毒抗体的出现。PWH的Mtb疾病状态对未来使用艾滋病毒广泛中和抗体进行预防或治疗以及诱导更好的体液免疫具有重要意义。
