Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), HUCA, Universidad de Oviedo, Oviedo, Spain.
Future Oncol. 2010 Jun;6(6):905-15. doi: 10.2217/fon.10.57.
Classically, aging has been defined as a general degeneration process that leads to the loss of corporal function. The loss of function caused by degeneration limits the maximum lifespan of all organisms and is linked to disease and cancer. Nevertheless, the molecular mechanisms behind aging and their connection to cancer are not well understood. NAD-dependent protein deacetylase enzymes, sirtuins, are emerging as a novel molecular link between aging and cancer due to their specific role in cell cycle regulation, antistress response and cell survival. This article reviews the contribution of sirtuins and environmental factors to ontogenic development, senescence and cancer.
传统上，衰老被定义为一种导致身体功能丧失的一般性退化过程。退化引起的功能丧失限制了所有生物体的最大寿命，并与疾病和癌症有关。然而，衰老的分子机制及其与癌症的联系尚不清楚。NAD 依赖性蛋白去乙酰化酶酶，即沉默调节蛋白，由于其在细胞周期调控、抗应激反应和细胞存活中的特定作用，成为衰老和癌症之间新的分子联系。本文综述了沉默调节蛋白和环境因素对个体发育、衰老和癌症的贡献。
