Bhattacharya Santanu, Bajaj Avinash
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India.
Chem Commun (Camb). 2009 Aug 21(31):4632-56. doi: 10.1039/b900666b. Epub 2009 Jul 3.
This feature article describes the recent developments in the design of cationic lipids and their applications in gene delivery. Various structure-activity investigations explaining the variations in gene transfection efficacies with respect to different molecular structures of the cationic lipids have been discussed. Gene transfer abilities are presented in relation to aggregation properties of different aqueous formulations such as cationic liposomes and surfactant aggregates from various amphiphiles and cationic lipids, as a function of their hydrophobic parts, linkers and head groups.
这篇专题文章描述了阳离子脂质设计的最新进展及其在基因递送中的应用。已经讨论了各种结构-活性研究，这些研究解释了阳离子脂质不同分子结构在基因转染效率方面的差异。根据不同水性制剂（如阳离子脂质体以及来自各种两亲物和阳离子脂质的表面活性剂聚集体）的聚集特性，作为其疏水部分、连接基和头部基团的函数，展示了基因转移能力。
