Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Punjab University, Chandigarh 160 014, India.
Behav Brain Res. 2009 Dec 28;205(2):414-20. doi: 10.1016/j.bbr.2009.07.020. Epub 2009 Jul 28.
Three decades after the coining of the term chronic fatigue syndrome, the diagnosis of this illness is still symptom based and the aetiology remains elusive. Chronic fatigue syndrome pathogenesis seems to be multifactorial and the possible involvement of immune system is supported. The present study was designed to evaluate the effects of the epigallocatechin gallate in a mouse model of immunologically induced chronic fatigue. On 19th day, after lipopolysaccharide/Brucella abortus administration, the mice showed significant increase in immobility period, post swim fatigue and thermal hyperalgesia. Behavioral deficits were coupled with enhanced oxidative-nitrosative stress as evident by increased lipid peroxidation, nitrite levels and decreased endogenous antioxidant enzymes (superoxide dismutase, reduced glutathione and catalase) and inflammation (increased levels of tumor necrosis factor-alpha and tissue growth factor-beta). Chronic treatment with epigallocatechin gallate restored these behavioral and biochemical alterations in mice. The present study points out towards the beneficial effect of epigallocatechin gallate in the amelioration of chronic fatigue syndrome and thus may provide a new, effective and powerful strategy to treat chronic fatigue syndrome.
coined coined the term chronic fatigue syndrome 术语“慢性疲劳综合征”术语“慢性疲劳综合征” 30 年后， 年后， 目前对这种疾病的诊断仍然基于症状， 目前对这种疾病的诊断仍然基于症状，其病因仍然难以捉摸。 其病因仍然难以捉摸。慢性疲劳综合征的发病机制似乎是多因素的， 慢性疲劳综合征的发病机制似乎是多因素的，免疫系统的可能参与得到了支持。 免疫系统的可能参与得到了支持。本研究旨在评估表没食子儿茶素没食子酸酯在免疫诱导的慢性疲劳小鼠模型中的作用。 在第 19 天， 天， 在脂多糖/布鲁氏菌流产杆菌给药后， 给药后， 小鼠表现出明显的不动期、游泳后疲劳和热痛觉过敏增加。 行为缺陷与氧化应激增加有关， 行为缺陷与氧化应激增加有关，表现为脂质过氧化、 脂质过氧化、亚硝酸盐水平升高和内源性抗氧化酶（超氧化物歧化酶、 超氧化物歧化酶、还原型谷胱甘肽和过氧化氢酶）和炎症（肿瘤坏死因子-α和组织生长因子-β水平升高）降低。 表没食子儿茶素没食子酸酯的慢性治疗恢复了小鼠的这些行为和生化改变。 本研究指出表没食子儿茶素没食子酸酯对慢性疲劳综合征的有益作用， 本研究指出表没食子儿茶素没食子酸酯对慢性疲劳综合征的有益作用， 因此可能为治疗慢性疲劳综合征提供一种新的、 因此可能为治疗慢性疲劳综合征提供一种新的、有效和强大的策略。
