Fayad Jose N, Makarem Andres O, Linthicum Fred H
Department of Histopathology, House Ear Institute, Los Angeles, CA 90057, USA.
Otolaryngol Head Neck Surg. 2009 Aug;141(2):247-52. doi: 10.1016/j.otohns.2009.03.031.
To evaluate new bone formation and fibrosis in implanted human temporal bones and relate that to neurosensory elements preservation.
Human temporal bone histopathology study.
Temporal bone laboratory.
Ten human temporal bones from eight patients with multichannel cochlear implants and one single-electrode implant were examined under light microscopy and reconstructed with AMIRA 4.1 3D reconstruction software. Volumes of new bone formation, fibrosis, and patent area were calculated in each bone.
The amount of fibrosis and new bone formation postimplantation varied among bones. There were no statistically significant relationships between age at implantation or duration of implantation and the overall amount of new tissue in the implanted ear. There was a relationship between total amount of new tissue and preservation of neurosensory elements only in segment I of the cochlea (Rho=-0.75, P<or=0.013). Most of the new tissue was located in segments I and II, segment III had little to no new tissue formation, and segment IV was clear in all of the subjects.
New tissue formation postimplantation was related to preservation of neurosensory elements primarily in segment I of the cochlea. In an era of hearing preservation surgery and hybrid cochlear implants, soft surgical techniques are advocated as a means to decrease surgical trauma.
评估植入人颞骨中的新骨形成和纤维化情况，并将其与神经感觉元件的保留情况相关联。
人颞骨组织病理学研究。
颞骨实验室。
对8例多通道人工耳蜗植入患者和1例单电极植入患者的10块人颞骨进行光学显微镜检查，并用AMIRA 4.1三维重建软件进行重建。计算每块骨中新骨形成、纤维化和开放区域的体积。
植入后纤维化和新骨形成的量在各骨之间有所不同。植入时的年龄或植入时间与植入耳中新组织的总量之间无统计学显著关系。仅在耳蜗的第I段，新组织总量与神经感觉元件的保留之间存在关系（Rho=-0.75，P≤0.013）。大部分新组织位于第I段和第II段，第III段几乎没有新组织形成，所有受试者的第IV段均清晰。
植入后新组织的形成主要与耳蜗第I段神经感觉元件的保留有关。在听力保留手术和混合人工耳蜗植入的时代，提倡采用轻柔的手术技术以减少手术创伤。
