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[急性和慢性给予苯丙胺对β-肾上腺素能机制功能紊乱大鼠刻板行为时间动态的重组作用]

[The reorganization of the temporal dynamics of stereotyped behavior in rats induced by the acute and chronic administration of fenamine in disordered functioning of the beta-adrenergic mechanisms].

作者信息

Popov A V, Arushanian E B

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1990 Sep-Oct;40(5):995-1000.

PMID:1964348
Abstract

Amphetamine-induced stereotyped behaviour of rats is a nonsteady oscillatory process. After combination of acute amphetamine and beta-adrenoblocker propranolol a lowering of amplitude and limitation of rhythmicity of stereotype were observed. But chronic propranolol intensified the stereotypy without usual increase of the number of short-period (2-3/min) fluctuations in the time course of the process. It is suggested that potentiation of behavioural disturbances by propranolol may be the result of blockade of pineal beta-adrenergic receptors and weakening of brain adaptive mechanisms function.

摘要

苯丙胺诱发的大鼠刻板行为是一个非稳定的振荡过程。急性给予苯丙胺和β-肾上腺素能阻滞剂普萘洛尔联合用药后,观察到刻板行为的振幅降低和节律受限。但长期给予普萘洛尔会加剧刻板行为,且在该过程的时间进程中,短周期(2 - 3次/分钟)波动的数量通常不会增加。提示普萘洛尔增强行为障碍可能是松果体β-肾上腺素能受体被阻断以及脑适应性机制功能减弱的结果。

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