Arushanian E B, Popov A V
Biull Eksp Biol Med. 1991 Mar;111(3):277-9.
Bilateral lesions of the dorsal striatum in rats attenuated amphetamine-induced stereotyped behaviour and limited its minute fluctuations with a decrease in intensity of short-period (minutes) waves. After lesion of the ventral region their intensity, on the contrary, rose. A higher sensitivity to chronic administration of amphetamine (2 weeks, 5 mg/kg daily) with an increase in intensity of rhythmic fluctuations of stereotyped behaviour was observed in animals with dorsal striatectomy. Directly opposite results were obtained in the second group of rats. It is suggested that the dorsal striatum is connected with the generation of high-frequency fluctuations in the time course of stereotyped behaviour and brings about a faster adaptation to amphetamine.
大鼠背侧纹状体的双侧损伤减弱了苯丙胺诱导的刻板行为，并限制了其微小波动，同时短周期（分钟）波的强度降低。相反，腹侧区域损伤后，其强度增加。在进行背侧纹状体切除术的动物中，观察到对慢性给予苯丙胺（2周，每日5mg/kg）具有更高的敏感性，刻板行为的节律性波动强度增加。在第二组大鼠中获得了完全相反的结果。有人认为，背侧纹状体与刻板行为时间过程中的高频波动产生有关，并导致对苯丙胺的更快适应。
