Arushanian E B, Popov A V
Farmakol Toksikol. 1990 Jan-Feb;53(1):17-9.
Amphetamine-induced stereotyped behavior is a nonsteady oscillatory process. In its structure waves with 2-3, 4-5 and 10-15 minute periods may be distinguished. In some animals (30%) after chronic amphetamine administration the stereotyped behavior was attenuated with reorganization of its rhythmical pattern but in other cases (35%) stereotype on the contrary increased. Tolerance developed in the animals which had initially the more pronounced stereotype with the predomination of short-period (2-3 min) waves on the chronogram. These animals demonstrated low locomotor activity in the opened field, greater immobility in the forced swimming test and better relearning in Y-maze.
苯丙胺诱导的刻板行为是一个不稳定的振荡过程。在其结构中，可以区分出周期为2 - 3分钟、4 - 5分钟和10 - 15分钟的波。在一些动物（30%）中，慢性给予苯丙胺后，刻板行为随着其节律模式的重新组织而减弱，但在其他情况下（35%），刻板行为反而增加。耐受性在最初刻板行为更明显且在时间图上以短周期（2 - 3分钟）波为主的动物中形成。这些动物在旷场试验中表现出低运动活性，在强迫游泳试验中表现出更大的不动性，在Y迷宫试验中表现出更好的再学习能力。
