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[骺板切除术和褪黑素对大鼠β-肾上腺素能机制功能紊乱中抗抑郁作用的影响]

[The influence of epiphysectomy and melatonin on the antidepressive effect in disordered function of the beta-adrenergic mechanisms in rats].

作者信息

Arushanian E B, Beĭer E V

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1992 Sep-Oct;42(5):993-7.

PMID:1336286
Abstract

After chronic administration of beta-adrenoblocker propranolol (1 mg/kg, 14 days) reorganization of time course of forced swimming with decrease of rhythmical index of depression was observed. Pinealectomy slightly attenuated, and melatonin (1 mg/kg) potentiated this effect. As proposed, antidepressive properties of beta-adrenoblockade primarily are not connected with pharmacological denervation of the pineal gland.

摘要

在长期给予β-肾上腺素能阻滞剂普萘洛尔(1毫克/千克,共14天)后,观察到强迫游泳时间进程的重组以及抑郁节律指数的降低。松果体切除略有减弱这种作用,而褪黑素(1毫克/千克)则增强了这种作用。如所提出的,β-肾上腺素能阻滞的抗抑郁特性主要与松果体的药理学去神经支配无关。

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1
[The influence of epiphysectomy and melatonin on the antidepressive effect in disordered function of the beta-adrenergic mechanisms in rats].[骺板切除术和褪黑素对大鼠β-肾上腺素能机制功能紊乱中抗抑郁作用的影响]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1992 Sep-Oct;42(5):993-7.
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