Galluzzi Samantha, Nicosia Franco, Geroldi Cristina, Alicandri Alberto, Bonetti Matteo, Romanelli Giuseppe, Zulli Roberto, Frisoni Giovanni B
Laboratory of Epidemiology Neuroimaging & Telemedicine (LENITEM), IRCCS San Giovanni di Dio FBF-The National Center for Research and Care of Alzheimer's Disease, Via Pilastroni 4, 25125, Brescia, Italy.
J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1312-5. doi: 10.1093/gerona/glp105. Epub 2009 Jul 30.
Cardiac autonomic dysfunction has been associated with cognitive impairment, but the underlying pathogenesis is complex and cerebral white matter lesions (WMLs) might be implicated.
Time and frequency heart rate variability (HRV) and visual rating of WMLs were carried out in 42 patients with mild cognitive impairment.
After adjustment for relevant demographic and clinical characteristics, including left ventricular mass, reduced HRV indices of parasympathetic (root mean square of successive difference of RR intervals, RMSSD) and sympathetic modulation (low-frequency [LF] power) were associated with increased WML score (RMSSD: B -0.30, 95% CI -0.52 to -0.08, p = .01; LF: B -0.24, 95% CI -0.46 to -0.02, p = .05). In a multiple-adjusted model, RMSSD was the major independent predictor of WMLs (B -0.35, 95% CI -0.57 to -0.13, p = .002).
The evidence for an independent association of cardiac autonomic dysfunction with WMLs might suggest its role in the pathogenesis of WMLs.
心脏自主神经功能障碍与认知障碍有关，但其潜在发病机制复杂，可能涉及脑白质病变（WMLs）。
对42例轻度认知障碍患者进行了时间和频率心率变异性（HRV）以及WMLs的视觉评分。
在调整了包括左心室质量在内的相关人口统计学和临床特征后，副交感神经（RR间期连续差值的均方根，RMSSD）和交感神经调节（低频[LF]功率）的HRV指标降低与WML评分增加相关（RMSSD：B -0.30，95%CI -0.52至-0.08，p = 0.01；LF：B -0.24，95%CI -0.46至-0.02，p = 0.05）。在多重调整模型中，RMSSD是WMLs的主要独立预测因子（B -0.35，95%CI -0.57至-0.13，p = 0.002）。
心脏自主神经功能障碍与WMLs独立相关的证据可能表明其在WMLs发病机制中的作用。
