Godin Ophélia, Tzourio Christophe, Maillard Pauline, Alpérovitch Annick, Mazoyer Bernard, Dufouil Carole
Inserm Unit 708 Neuroepidemiology, Hôpital la Salpétrière, Paris, France.
Stroke. 2009 Oct;40(10):3186-90. doi: 10.1161/STROKEAHA.109.555839. Epub 2009 Jul 30.
The relationship between white matter lesions (WMLs) and the apolipoprotein E genotype has been controversial from cross-sectional studies and no longitudinal finding has been reported. We investigated whether the apolipoprotein E genotype influences baseline and evolution over 4-year follow-up of WML volumes in a population-based sample of 1779 nondemented subjects aged 65 to 80 years old at enrollment.
The sample consisted of 3C-Dijon study participants who had 2 cerebral MRIs, at entry and at 4-year follow-up. WML volumes were estimated using a fully automatic procedure. We performed analysis of covariance to evaluate the relationship between apolipoprotein E genotype and WML load and progression.
Multivariable analyses showed that epsilon4epsilon4 individuals had both significantly higher WML volume at baseline and higher WML increase over 4-year follow-up than noncarriers and heterozygous of the epsilon4 allele for apolipoprotein E genotype.
These findings suggest it might be important to take into account WML severity when assessing the relationship between apolipoprotein E and dementia.
白质病变（WMLs）与载脂蛋白E基因型之间的关系在横断面研究中一直存在争议，且尚无纵向研究结果报道。我们调查了在一个基于人群的样本中，载脂蛋白E基因型是否会影响1779名年龄在65至80岁之间、入组时无痴呆的受试者在4年随访期间WML体积的基线水平和变化情况。
样本包括3C - 第戎研究的参与者，他们在入组时和4年随访时进行了两次脑部MRI检查。使用全自动程序估计WML体积。我们进行了协方差分析，以评估载脂蛋白E基因型与WML负荷及进展之间的关系。
多变量分析显示，与载脂蛋白E基因型的非携带者和ε4等位基因杂合子相比，ε4ε4个体在基线时的WML体积显著更高，且在4年随访期间WML增加幅度更大。
这些发现表明，在评估载脂蛋白E与痴呆之间的关系时，考虑WML严重程度可能很重要。
