Bakuridze A D, Nikolaev S M, Tsagarenshvili N T, Kurdiani N G, Mikaia G A
Georgian Med News. 2009 Jul-Aug(172-173):89-91.
The dry extract from the terrestrial parts of Gentiana Lutea was received in accordance to the developed by us general technological scheme. Study of the pharmacological influence of obtained extract on the coagulating properties of blood revealed that after its per os instillation into experimental animals the time of the formation of active thromboplastin reliably increases, while the time of thrombin and fibrinous cluster formation is shortened in comparison with those indices in the animals, that did not receive phyto-preparation, at the same time morphological appearance of the peripheral blood remains unchanged. Dry extract of terrestrial parts of Gentiana Lutea prepared in accordance to the technology recommended by us, together with widely known pharmacological effects, is characterized with new activity - influence on haemostasis. Obtained preliminary data concerning influence of the extract on coagulation of the blood request further deep studies of its mechanism. Revealed new activity of the terrestrial parts of Gentiana Lutea and the studies of the mechanism of its activity will serve in future as a basis for the recommendation of its use in new nosology. Terrestrial parts of Gentiana lutea L. are proposed as an alternative of the underground parts of the plant. Alongside with that, it is expedient to continue the studies devoted to the development of the haemostatic remedies of plant origin with systemic and local action (sponges, films, skin glues) from terrestrial parts of Gentiana lutea L.
按照我们制定的通用技术方案获得了黄龙胆地上部分的干提取物。对所得提取物对血液凝固特性的药理影响研究表明，将其经口灌胃给实验动物后，活性凝血活酶形成时间可靠地增加，而与未接受植物制剂的动物相比，凝血酶和纤维蛋白凝块形成时间缩短，同时外周血的形态外观保持不变。按照我们推荐的技术制备的黄龙胆地上部分干提取物，除了具有广为人知的药理作用外，还具有新的活性——对止血的影响。关于提取物对血液凝固影响的初步数据需要对其作用机制进行进一步深入研究。黄龙胆地上部分新活性的发现及其活性机制的研究将为将来推荐其用于新的疾病分类学提供依据。建议将黄龙胆地上部分作为该植物地下部分的替代品。与此同时，继续开展致力于开发具有全身和局部作用（海绵、薄膜、皮肤胶水）的源自黄龙胆地上部分的植物源性止血药物的研究是适宜的。
