Institute for Medicinal Plants Research, Tadeusa Koscuska 1, Belgrade, 11000 Serbia.
Phytother Res. 2010 Nov;24(11):1693-6. doi: 10.1002/ptr.3225.
Radioprotective/sensitizing actions of Gentiana lutea aqueous-ethanol extract and mangiferin on radiation-induced effects on different types of cells were investigated. The study focused on the decreasing survival of normal human immunocompetent cells, the survival of the malignant cells in vitro, and the survival of ex vivo irradiated cells before and after consumption of the extract by healthy volunteers. The in vitro experiments showed that mangiferin could inhibit cytotoxic action of ionizing irradiation (doses of 6 and 8 Gy) only on normal resting human PBMC, not stimulated for proliferation. Orally consumed G. lutea extract showed the potential to reduce the cytotoxic effect of x-ray irradiation on normal human immunocompetent cells PBMC of some healthy people, without changing the susceptibility of malignant cells to be destroyed by irradiation. Since the radioprotective effect was individually dependent, further clinical studies are needed.
研究了獐牙菜水-乙醇提取物和芒果苷对不同类型细胞辐射诱导效应的放射防护/增敏作用。该研究集中于降低正常人类免疫活性细胞的存活率、体外恶性细胞的存活率以及健康志愿者摄入提取物前后体外辐照细胞的存活率。体外实验表明，芒果苷仅能抑制正常静止人外周血单个核细胞（未刺激增殖）的细胞毒性作用。口服獐牙菜提取物具有降低正常人外周血单个核细胞（一些健康人）X 射线照射细胞毒性作用的潜力，而不改变恶性细胞对照射破坏的敏感性。由于放射防护作用具有个体依赖性，因此需要进一步的临床研究。
