Kneser Matthias, Kohlmann Thomas, Pokorny Jens, Tost Frank
Department of Ophthalmology, EMA University, Greifswald, Germany.
Med Sci Monit. 2009 Aug;15(8):CR436-41.
The present study investigates the regulative retinal vascular answer to flicker as measured by Dynamic Vessel Analysis (DVA) in relation to age.
MATERIAL/METHODS: 52 clinically healthy volunteers (age 20-78 years) free of cardiovascular risk factors according to an extensive medical history, lab values and blood pressure (BP) were examined by retinal DVA. The regulative arterial and venous responses to flicker were recorded with a Retinal Vessel Analyzer (Imedos, Jena/Germany).
The retinal arterial regulative amplitude, consisting of a dilation and constriction component, diminished by 45% with age, mainly due to the constricting component diminishing by 75%. The venous response to flicker was unaltered.
The vascular regulative amplitude as well as its constriction part are observable in retinal arteries. They undergo major reduction in healthy individuals during adult lifetime. The results can be explained by the change of biomechanical properties of the vessel wall as well as physiological changes of the vascular endothelial function with age. Hereby the DVA technique shows good potential for investigating cardiovascular aspects in preventive medicine. Whenever doing functional DVA testing these results should be taken in account. The data obtained are first normative age related DVA data.
本研究通过动态血管分析（DVA）测量视网膜血管对闪烁光的调节反应，并研究其与年龄的关系。
材料/方法：根据详尽的病史、实验室检查结果和血压（BP），选取52名无心血管危险因素的临床健康志愿者（年龄20 - 78岁），采用视网膜DVA进行检查。使用视网膜血管分析仪（德国耶拿Imedos公司）记录动脉和静脉对闪烁光的调节反应。
视网膜动脉调节幅度，包括扩张和收缩成分，随年龄增长下降了45%，主要是由于收缩成分下降了75%。静脉对闪烁光的反应未改变。
视网膜动脉中可观察到血管调节幅度及其收缩部分。在健康个体的成年期，它们会大幅降低。这些结果可以通过血管壁生物力学特性的变化以及血管内皮功能随年龄的生理变化来解释。由此可见，DVA技术在预防医学心血管方面的研究具有良好潜力。进行功能性DVA测试时应考虑这些结果。所获得的数据是首批与年龄相关的DVA规范数据。
