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Apoptotic cell blebs: repositories of autoantigens and contributors to immune context.

作者信息

Suber Tomeka, Rosen Antony

出版信息

Arthritis Rheum. 2009 Aug;60(8):2216-9. doi: 10.1002/art.24715.

DOI:10.1002/art.24715
PMID:19644864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3638860/
Abstract
摘要

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Apoptotic cell blebs: repositories of autoantigens and contributors to immune context.凋亡细胞小泡：自身抗原的储存库及免疫环境的促成因素。
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2
The consequences of apoptosis in autoimmunity.细胞凋亡在自身免疫中的后果。
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3
Autoimmune disease: skin deep but complex.自身免疫性疾病：累及皮肤但情况复杂。
Nature. 2007 Oct 4;449(7162):551-3. doi: 10.1038/nature05893.
4
Cellular and molecular pathogenic mechanisms of insulin-dependent diabetes mellitus.胰岛素依赖型糖尿病的细胞和分子致病机制。
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5
Both early and late apoptotic blebs are taken up by DC and induce IL-6 production.早期和晚期凋亡小泡均被树突状细胞摄取并诱导白细胞介素-6的产生。
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6
Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17.通过摄取凋亡小泡而成熟的小鼠树突状细胞可诱导T细胞产生白细胞介素-17。
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7
Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses.聚集素促进凋亡细胞的清除，并防止凋亡细胞诱导的自身免疫反应。
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8
Dendritic cells in tolerance induction for the treatment of autoimmune diseases.树突状细胞在诱导免疫耐受治疗自身免疫性疾病中的作用。
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Autoantigen signalling through chemokine receptors.
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Blebs and apoptotic bodies are B cell autoantigens.水泡和凋亡小体是B细胞自身抗原。
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Cytotoxic CD8 T cells may be drivers of tissue destruction in Sjögren's syndrome.细胞毒性 CD8 T 细胞可能是干燥综合征中组织破坏的驱动因素。
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Can Antinuclear Antibodies Have a Pathogenic Role in Systemic Sclerosis?抗核抗体在系统性硬化症中是否具有致病性作用？
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Apoptosis-induced translocation of centromere protein F in its corresponding autoantibody production in hepatocellular carcinoma.凋亡诱导的着丝粒蛋白 F 在肝癌中与其相应自身抗体产生的易位。
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Leptin enhances availability of apoptotic cell-derived self-antigen in systemic lupus erythematosus.瘦素增强了系统性红斑狼疮中凋亡细胞衍生的自身抗原的可用性。
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The role of antigen specificity in the binding of murine monoclonal anti-DNA antibodies to microparticles from apoptotic cells.抗原特异性在鼠单克隆抗DNA抗体与凋亡细胞微粒结合中的作用。
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The expression of HMGB1 on microparticles from Jurkat and HL-60 cells undergoing apoptosis in vitro.体外凋亡的 Jurkat 和 HL-60 细胞来源微粒上 HMGB1 的表达。
Scand J Immunol. 2014 Aug;80(2):101-10. doi: 10.1111/sji.12191.
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Polyubiquitinated proteins, proteasome, and glycogen characterize the particle-rich cytoplasmic structure (PaCS) of neoplastic and fetal cells.多聚泛素化蛋白、蛋白酶体和糖原是肿瘤细胞和胎儿细胞富含颗粒的胞质结构（PaCS）的特征。
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Apoptotic blebs from leukemic cells as a preferred source of tumor-associated antigen for dendritic cell-based vaccines.白血病细胞凋亡小泡作为树突状细胞疫苗肿瘤相关抗原的首选来源。
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PaCS is a novel cytoplasmic structure containing functional proteasome and inducible by cytokines/trophic factors.PaCS是一种新型的细胞质结构，含有功能性蛋白酶体，可被细胞因子/营养因子诱导产生。
PLoS One. 2013 Dec 17;8(12):e82560. doi: 10.1371/journal.pone.0082560. eCollection 2013.
10
The properties of microparticles from RAW 264.7 macrophage cells undergoing in vitro activation or apoptosis.体外激活或凋亡的 RAW 264.7 巨噬细胞来源的微粒的特性。
Innate Immun. 2014 Apr;20(3):239-48. doi: 10.1177/1753425913492552. Epub 2013 Jul 9.

本文引用的文献

1
Autoantibodies to tumor-associated antigens: reporters from the immune system.肿瘤相关抗原自身抗体：来自免疫系统的报告分子
Immunol Rev. 2008 Apr;222:328-40. doi: 10.1111/j.1600-065X.2008.00611.x.
2
Engulfment of apoptotic cells: signals for a good meal.凋亡细胞的吞噬：美餐的信号。
Nat Rev Immunol. 2007 Dec;7(12):964-74. doi: 10.1038/nri2214.
3
Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease.具有免疫活性的自身抗原：Toll样受体在慢性炎症性疾病发生发展中的作用
Annu Rev Immunol. 2007;25:419-41. doi: 10.1146/annurev.immunol.22.012703.104514.
4
Apoptosis and systemic lupus erythematosus.细胞凋亡与系统性红斑狼疮
Rheum Dis Clin North Am. 2004 Aug;30(3):505-27, viii-ix. doi: 10.1016/j.rdc.2004.04.006.
5
Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice.MFG-E8 缺陷小鼠中的自身免疫性疾病与凋亡细胞摄取受损
Science. 2004 May 21;304(5674):1147-50. doi: 10.1126/science.1094359.
6
Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells.组氨酰-tRNA合成酶和天冬酰胺酰-tRNA合成酶是肌炎中的自身抗原，可激活T淋巴细胞和未成熟树突状细胞上的趋化因子受体。
J Exp Med. 2002 Sep 16;196(6):781-91. doi: 10.1084/jem.20020186.
7
The trigger to cell death determines the efficiency with which dying cells are cleared by neighbours.细胞死亡的触发因素决定了相邻细胞清除垂死细胞的效率。
Cell Death Differ. 2001 Jul;8(7):734-46. doi: 10.1038/sj.cdd.4400867.
8
The induction of tolerance by dendritic cells that have captured apoptotic cells.捕获凋亡细胞的树突状细胞诱导的耐受性。
J Exp Med. 2000 Feb 7;191(3):411-6. doi: 10.1084/jem.191.3.411.
9
Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease.作为凋亡蛋白酶底物的自身抗原：对系统性自身免疫病发病机制的影响
Cell Death Differ. 1999 Jan;6(1):6-12. doi: 10.1038/sj.cdd.4400460.
10
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies.纯合子C1q缺乏会导致与多个凋亡小体相关的肾小球肾炎。
Nat Genet. 1998 May;19(1):56-9. doi: 10.1038/ng0598-56.