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CMV 糖蛋白 B 疫苗联合 MF59 佐剂的研发与疗效证据。

Development and evidence for efficacy of CMV glycoprotein B vaccine with MF59 adjuvant.

机构信息

Department of Pediatrics, University of Alabama at Birmingham, USA.

出版信息

J Clin Virol. 2009 Dec;46 Suppl 4(Suppl 4):S73-6. doi: 10.1016/j.jcv.2009.07.002. Epub 2009 Jul 31.

DOI:10.1016/j.jcv.2009.07.002
PMID:19647480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2805195/
Abstract

A vaccine comprised of recombinant cytomegalovirus (CMV) envelope glycoprotein B (gB) with MF59 adjuvant developed in the 1990s recently was recently found to have efficacy for prevention of CMV infection in a phase 2 clinical trial in young mothers. This review briefly considers the rationale for gB as a vaccine antigen, the history of this CMV gB vaccine and the data supporting vaccine efficacy.

摘要

一种由重组巨细胞病毒（CMV）包膜糖蛋白 B（gB）与 MF59 佐剂组成的疫苗，于 20 世纪 90 年代开发成功，最近在一项针对年轻母亲的 2 期临床试验中发现对预防 CMV 感染有效。这篇综述简要讨论了 gB 作为疫苗抗原的原理、这种 CMV gB 疫苗的历史以及支持疫苗有效性的数据。

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本文引用的文献

1
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N Engl J Med. 2009 Mar 19;360(12):1191-9. doi: 10.1056/NEJMoa0804749.
2
Safety of MF59 adjuvant.MF59佐剂的安全性。
Vaccine. 2008 Jun 19;26(26):3209-22. doi: 10.1016/j.vaccine.2008.03.093. Epub 2008 Apr 21.
3
Safety and immunogenicity of a bivalent cytomegalovirus DNA vaccine in healthy adult subjects.一种二价巨细胞病毒DNA疫苗在健康成年受试者中的安全性和免疫原性。
Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies.
人巨细胞病毒gH/gL/gO与血小板衍生生长因子受体α（PDGFRα）的结合提供了一种调节信号，可激活融合蛋白gB，而该信号可被中和抗体阻断。
J Virol. 2025 May 20;99(5):e0003525. doi: 10.1128/jvi.00035-25. Epub 2025 Apr 9.
4
The pentameric complex is not required for congenital CMV transmission in seronegative rhesus macaques.对于血清阴性的恒河猴而言，先天性巨细胞病毒传播并不需要五聚体复合物。
Sci Transl Med. 2025 Mar 12;17(789):eadm8961. doi: 10.1126/scitranslmed.adm8961.
5
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bioRxiv. 2025 Jan 8:2025.01.08.631902. doi: 10.1101/2025.01.08.631902.
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T cell inducing vaccine against cytomegalovirus immediate early 1 (IE1) protein provides high level cross strain protection against congenital CMV.针对巨细胞病毒即刻早期1（IE1）蛋白的T细胞诱导疫苗可提供高水平的针对先天性巨细胞病毒的交叉株保护。
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J Virol. 2022 Sep 14;96(17):e0083122. doi: 10.1128/jvi.00831-22. Epub 2022 Aug 24.
J Infect Dis. 2008 Jun 15;197(12):1634-42. doi: 10.1086/588385.
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