成年期分裂型特质的早期起源。
Early-life origins of schizotypal traits in adulthood.
作者信息
Lahti Jari, Raïkkönen Katri, Sovio Ulla, Miettunen Jouko, Hartikainen Anna-Liisa, Pouta Anneli, Taanila Anja, Joukamaa Matti, Järvelin Marjo-Riitta, Veijola Juha
机构信息
Department of Psychology, University of Helsinki, FI 00014 University of Helsinki, Finland.
出版信息
Br J Psychiatry. 2009 Aug;195(2):132-7. doi: 10.1192/bjp.bp.108.054387.
BACKGROUND
Although schizotypal traits, such as anhedonia and aberrant perceptions, may increase the risk for schizophrenia-spectrum disorders, little is known about early-life characteristics that predict more pronounced schizotypal traits.
AIMS
To examine whether birth size or several other early-life factors that have been previously linked with schizophrenia predict schizotypal traits in adulthood.
METHOD
Participants of the Northern Finland 1966 Birth Cohort Study (n = 4976) completed a questionnaire on positive and negative schizotypal traits at the age of 31 years.
RESULTS
Lower placental weight, lower birth weight and smaller head circumference at 12 months predicted elevated positive schizotypal traits in women after adjusting for several confounders (P<0.02). Moreover, higher gestational age, lower childhood family socioeconomic status, undesirability of pregnancy, winter/autumn birth, higher birth order and maternal smoking during pregnancy predicted some augmented schizotypal traits in women, some in men and some in both genders.
CONCLUSIONS
The results point to similarities in the aetiology of schitzotypal traits and schizophrenia-spectrum disorders.
背景
尽管分裂型特质，如快感缺乏和异常感知，可能会增加精神分裂症谱系障碍的风险，但对于预测更明显分裂型特质的早期生活特征知之甚少。
目的
研究出生时的大小或其他一些先前与精神分裂症相关的早期生活因素是否能预测成年后的分裂型特质。
方法
1966年芬兰北部出生队列研究的参与者（n = 4976）在31岁时完成了一份关于阳性和阴性分裂型特质的问卷。
结果
在调整了几个混杂因素后，较低的胎盘重量、较低的出生体重和12个月时较小的头围预示着女性阳性分裂型特质升高（P<0.02）。此外，较高的孕周、较低的童年家庭社会经济地位、意外怀孕、冬/秋季出生、较高的出生顺序以及孕期母亲吸烟预示着女性、部分男性以及部分男女两性的一些分裂型特质增加。
结论
结果表明分裂型特质和精神分裂症谱系障碍在病因学上存在相似性。
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