Singh S, Jain L, Pandey M B, Singh U P, Pandey V B
Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Folia Microbiol (Praha). 2009;54(3):204-6. doi: 10.1007/s12223-009-0032-7. Epub 2009 Aug 2.
The isoquinoline alkaloids hunnemanine and norsanguinarine have been isolated from methanolic extract of the whole plant of Eschscholzia californica. These two alkaloids were checked for their antifungal activity against phytopathogenic fungi Alternaria melongenae, A. brassicola, A. brassicae, Curvularia lunata, C. maculans, Helminthosporium pennisetti, H. oryzae, H. turcicum, Fusarium undum and F. lini. Hunnemanine exhibited 100 % inhibition of spore germination of A. brassicae, H. pennisetti and F. lini at 1000 ppm whereas norsanguinarine exhibited 100 % inhibition of A. brassicicola and C. maculans at this concentration.
异喹啉生物碱洪曼宁和去甲血根碱已从加利福尼亚罂粟全株的甲醇提取物中分离出来。检测了这两种生物碱对植物病原真菌链格孢、芸苔链格孢、甘蓝链格孢、新月弯孢霉、黄斑弯孢霉、狼尾草长蠕孢、稻长蠕孢、玉米大斑病菌、腐皮镰刀菌和亚麻镰刀菌的抗真菌活性。洪曼宁在1000 ppm时对甘蓝链格孢、狼尾草长蠕孢和亚麻镰刀菌的孢子萌发表现出100%的抑制作用，而去甲血根碱在此浓度下对芸苔链格孢和黄斑弯孢霉表现出100%的抑制作用。
