Nasreen A, Akhtar F, Shekhani M S, Clardy J, Parvez M, Choudhary M I
H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan.
J Nat Prod. 1997 May;60(5):472-4. doi: 10.1021/np960663n.
The roots of Delphinium denudatum have yielded a new diterpenoid alkaloid, 8-acetylheterophyllisine (1), in addition to the known alkaloids vilmorrianone (2), panicutine (3), denudatine (4), isotalatizidine (5), and condelphine (6), as well as 3-hydroxy-2-methyl-4H-pyran-4-one (7). Compounds 1, 3, and 7 have not been isolated from this plant previously. The structures of compounds 1, 3, and 7 were determined through spectral and X-ray diffraction analyses. Compounds 1-3 have shown antifungal activity against a number of human pathogenic fungi.
除了已知生物碱滇紫堇酮（2）、银莲花碱（3）、裸茎翠雀碱（4）、异塔拉地嗪（5）和中乌头碱（6）以及3-羟基-2-甲基-4H-吡喃-4-酮（7）外，裸茎翠雀的根还产生了一种新的二萜生物碱，8-乙酰基异叶碱（1）。化合物1、3和7以前未曾从该植物中分离得到。通过光谱和X射线衍射分析确定了化合物1、3和7的结构。化合物1-3对多种人类致病真菌表现出抗真菌活性。
