Pasquali Renato, Gambineri Alessandra
University Alma Mater Studiorum, S. Orsola-Malpighi Hospital, Division of Endocrinology, Department of Clinical Medicine, Bologna, Italy.
Expert Opin Ther Targets. 2009 Oct;13(10):1205-26. doi: 10.1517/14728220903190699.
Targeting insulin resistance may result in a list of benefits for women with PCOS, including hormonal, metabolic and ovulatory (and fertility) improvements. The therapeutic strategy to treat PCOS should however depend on the clinical situation, the phenotype, the degree of androgen excess, age, the presence of infertility and the woman's desire to conceive, the presence of obesity and, finally, the spectrum of metabolic abnormalities and the need to treat or prevent long-term associated comorbidities. According to the needs, therapeutic options include, alone or in combination, lifestyle management, particularly in the presence of obesity, the use of insulin sensitizers, metformin and thiazolidinediones, antiandrogens or estro-progestins.
针对胰岛素抵抗可能会给患有多囊卵巢综合征（PCOS）的女性带来一系列益处，包括激素、代谢及排卵（和生育能力）方面的改善。然而，治疗PCOS的治疗策略应取决于临床情况、表型、雄激素过量程度、年龄、不孕情况以及女性的受孕意愿、肥胖状况，最后还取决于代谢异常的范围以及治疗或预防长期相关合并症的需求。根据具体需求，治疗选择包括单独或联合采用生活方式管理，尤其是在存在肥胖的情况下，使用胰岛素增敏剂、二甲双胍和噻唑烷二酮类药物、抗雄激素药物或雌激素 - 孕激素。
