Ortega-Pacheco A, Jiménez-Coello M, Gutiérrez-Blanco E, Acosta-Viana K Y, Guzmán-Marín E, Zavala-Sánchez M A, Montalvo-Beltrán N E, Pérez-Gutiérrez M S
Departamento de Medicina Interna y Cirugía, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.
Reprod Domest Anim. 2010 Dec;45(6):1126-9. doi: 10.1111/j.1439-0531.2009.01503.x.
Papaya seeds (Carica papaya Linn) have been found to have a significant effect on sperm characteristics in some mammals, including humans, but no studies have investigated the effects on dogs. In the present study, a significant decrease in sperm concentration was observed in a group of dogs treated with extracts from washed papaya seeds, but no decrease was observed in the group of dogs treated with non-washed seeds. An important effect of extract components from washed seeds such as fatty acids is probably involved in the reduction of sperm production because of Sertoli cell damage, as has been suggested for langur monkeys. Dilution of the active components in the non-washed papaya seeds or interference with some of the components may reduce the expected effect on spermatogenesis. This first report on the effects of a chloroformic extract of papaya seeds in dogs suggests that an increased dose is necessary to achieve azoospermia.
番木瓜籽（番木瓜）已被发现对包括人类在内的一些哺乳动物的精子特性有显著影响，但尚无研究调查其对犬类的影响。在本研究中，一组用洗净的番木瓜籽提取物处理的犬类精子浓度显著下降，但用未洗净种子处理的犬类组未观察到下降。如对叶猴的研究表明，洗净种子的提取物成分（如脂肪酸）的重要作用可能是由于支持细胞损伤导致精子生成减少。未洗净的番木瓜籽中活性成分的稀释或某些成分的干扰可能会降低对精子发生的预期效果。这份关于番木瓜籽氯仿提取物对犬类影响的首次报告表明，需要增加剂量才能达到无精子症。
