可乐定透皮贴剂治疗儿童抽动秽语综合征的疗效

[Efficacy of clonidine transdermal patch for treatment of Tourette's syndrome in children].

作者信息

Kang Hua, Zhang Yue-Fang, Jiao Fu-Yong, Guo Xiang-Yang, Gao Xiao-Min

机构信息

Department of Pediatrics, Shaanxi Province People's Hospital, Xi'an 710068, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2009 Jul;11(7):537-9.

PMID:19650984

Abstract

OBJECTIVE

Children with Tourette's syndrome (TS) have a poor treatment compliance due to side effects and inconvenient administration of oral drugs. This study explored the efficacy and safety of clonidine transdermal patch for treating TS in children.

METHODS

A total of 119 children with TS were randomly treated with the clonidine transdermal patch (n=65) or with oral haloperidol (n=54). The therapeutic efficacy was assessed based on the results of the Yale Global Tic Severity Scale (YGTSS) 4 weeks after treatment.

RESULTS

The clonidine transdermal patch group showed a higher reduction in the overall tic symptom scores (61.5+/-7.5%) than that in the haloperidol group (41.0+/-6.3%; p<0.05). Clonidine transdermal patch treatment was effective in 53 patients (81.5%) and 36 patients (67.5%) showed effective to oral haloperidol (p>0.05). Mild side effects (decrease of blood pressure and dizziness) were observed in 1 patient in the clonidine transdermal patch group. Mild hypermyotonia, drowsiness or lassitude as side effects occurred in 6 patients in the haloperidol group.

CONCLUSIONS

Clonidine transdermal patch is effective for the treatment of TS in children and its side effects are mild and rare.

摘要

目的

由于口服药物的副作用和给药不便，抽动秽语综合征（TS）患儿的治疗依从性较差。本研究探讨可乐定透皮贴剂治疗儿童TS的疗效和安全性。

方法

119例TS患儿随机接受可乐定透皮贴剂治疗（n = 65）或口服氟哌啶醇治疗（n = 54）。治疗4周后，根据耶鲁综合抽动严重程度量表（YGTSS）的结果评估治疗效果。

结果

可乐定透皮贴剂组的总体抽动症状评分降低幅度（61.5±7.5%）高于氟哌啶醇组（41.0±6.3%；p<0.05）。可乐定透皮贴剂治疗对53例患者有效（81.5%），36例患者口服氟哌啶醇有效（67.5%）（p>0.05）。可乐定透皮贴剂组有1例患者出现轻度副作用（血压下降和头晕）。氟哌啶醇组有6例患者出现轻度肌张力亢进、嗜睡或倦怠等副作用。