Faber E S Louise
The University of Queensland, Queensland Brain Institute, Brisbane, QLD, 4072, Australia.
Cell Biochem Biophys. 2009;55(3):127-39. doi: 10.1007/s12013-009-9062-7. Epub 2009 Aug 5.
Small conductance (SK) channels are calcium-activated potassium channels that, when cloned in 1996, were thought solely to contribute to the afterhyperpolarisation that follows action potentials, and to control repetitive firing patterns of neurons. However, discoveries over the past few years have identified novel roles for SK channels in controlling dendritic excitability, synaptic transmission and synaptic plasticity. More recently, modulation of SK channel calcium sensitivity by casein kinase 2, and of SK channel trafficking by protein kinase A, have been demonstrated. This article will discuss recent findings regarding the function and modulation of SK channels in central neurons.
小电导（SK）通道是钙激活钾通道，1996年被克隆时，人们认为它仅对动作电位后的超极化后电位起作用，并控制神经元的重复放电模式。然而，过去几年的研究发现，SK通道在控制树突兴奋性、突触传递和突触可塑性方面具有新的作用。最近，已证实酪蛋白激酶2对SK通道钙敏感性的调节以及蛋白激酶A对SK通道转运的调节。本文将讨论有关中枢神经元中SK通道功能和调节的最新研究结果。
