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肝移植后持续性门体分流导致间歇性肝性脑病。

Persistent portosystemic shunts after liver transplantation causing episodic hepatic encephalopathy.

机构信息

Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC 27599-7080, USA.

出版信息

Dig Dis Sci. 2010 Jun;55(6):1794-8. doi: 10.1007/s10620-009-0901-6. Epub 2009 Aug 5.

Abstract

We describe two cases of post liver transplant encephalopathy caused by persistent portosystemic shunts despite good graft function. Such recurrence of encephalopathy due to persistent shunting has not been reported in the deceased donor liver transplant literature. Our patients had episodic hepatic encephalopathy concordant with elevated serum ammonia levels due to well documented persistent portosystemic shunts. In one of our cases, the shunt was obliterated via coil embolization. This patient's encephalopathy resolved completely and has not recurred over seven months of follow up. The second patient has declined an intervention, but has remained symptom free on maintenance lactulose and rifaximin.

摘要

我们描述了两例肝移植后脑病病例,尽管移植物功能良好,但仍存在持续性门体分流。这种由于持续性分流导致的脑病复发在已故供体肝移植文献中尚未报道。我们的患者因有明确记录的持续性门体分流而出现间歇性肝性脑病,伴有血清氨水平升高。在我们的一个病例中,通过线圈栓塞闭塞了分流。该患者的脑病完全缓解,随访 7 个月未再复发。第二位患者拒绝介入治疗,但仍使用乳果糖和利福昔明维持无症状。

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Clinical management of type C hepatic encephalopathy.C 型肝性脑病的临床管理。
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本文引用的文献

1
Long-term follow-up of portal hypertension after liver transplantation in children.儿童肝移植后门静脉高压的长期随访
Pediatr Transplant. 2009 Mar;13(2):206-9. doi: 10.1111/j.1399-3046.2008.00993.x. Epub 2008 Jun 18.
3
Hepatic Encephalopathy.肝性脑病
Am J Gastroenterol. 2001 Jul;96(7):1968-76. doi: 10.1111/j.1572-0241.2001.03964.x.

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