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肝移植术后血管并发症管理中的影像学与介入治疗

Imaging and Intervention in the Management of Vascular Complications Following Liver Transplantation.

作者信息

Kubihal Vijay, Sasturkar Shridhar, Mukund Amar

机构信息

Department of Interventional Radiology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India.

Department of Hepato-Pancreato-Biliary Surgery, Institute of Liver and Biliary Sciences, New Delhi, 110070, India.

出版信息

J Clin Exp Hepatol. 2023 Sep-Oct;13(5):854-868. doi: 10.1016/j.jceh.2023.03.010. Epub 2023 Mar 31.

Abstract

Liver transplantation is the treatment of choice in majority of the patients with end stage liver disease. Vascular complication following liver transplantation is seen in around 7-13% of the patients and is associated with graft dysfunction and high morbidity and mortality. Early diagnosis and prompt treatment are crucial in management of these patients. Advances in interventional radiology have significantly improved the management of vascular complications using minimally invasive percutaneous approach. Endovascular management is preferred in patients with late hepatic artery thrombosis, or stenosis, whereas retransplantation, surgical revision, or endovascular management can be considered in patients with early hepatic artery thrombosis or stenosis. Hepatic artery pseudoaneurysm, arterioportal fistula, and splenic artery steal syndrome are often treated by endovascular means. Endovascular management is also preferred in patients with symptomatic portal vein stenosis, early portal vein thrombosis, and symptomatic late portal vein thrombosis, whereas surgical revision or retransplantation is preferred in patients with perioperative portal vein thrombosis occurring within 3 days of transplantation. Venoplasty with or without stent placement can be considered in patients with hepatic venous outflow tract or inferior vena cava obstruction. Transjugular intrahepatic portosystemic shunt (TIPS) may be required in transplant recipients who develop cirrhosis, often, secondary to disease recurrence, or chronic rejection. Indications for TIPS remain same in the transplant patients; however, major difference is altered vascular anatomy, for which adjunct techniques may be required to create TIPS.

摘要

肝移植是大多数终末期肝病患者的首选治疗方法。肝移植后的血管并发症在约7% - 13%的患者中可见,且与移植肝功能障碍及高发病率和死亡率相关。早期诊断和及时治疗对这些患者的管理至关重要。介入放射学的进展显著改善了使用微创经皮方法对血管并发症的管理。对于晚期肝动脉血栓形成或狭窄的患者,血管内治疗是首选,而对于早期肝动脉血栓形成或狭窄的患者,可考虑再次移植、手术修复或血管内治疗。肝动脉假性动脉瘤、动脉门静脉瘘和脾动脉盗血综合征通常通过血管内方法治疗。对于有症状的门静脉狭窄、早期门静脉血栓形成和有症状的晚期门静脉血栓形成的患者,血管内治疗也是首选,而对于移植后3天内发生的围手术期门静脉血栓形成的患者,手术修复或再次移植是首选。对于肝静脉流出道或下腔静脉阻塞的患者,可考虑进行有或无支架置入的静脉成形术。对于常因疾病复发或慢性排斥继发肝硬化的移植受者,可能需要行经颈静脉肝内门体分流术(TIPS)。TIPS在移植患者中的适应证保持不变;然而,主要区别在于血管解剖结构改变,为此可能需要辅助技术来创建TIPS。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d27/10483010/25afe8a155d9/ga1.jpg

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