壬苯醇醚-9低聚物的制备液相色谱分离及其通过¹H-NMR和质谱进行的表征。
Preparative liquid chromatographic separation of the oligomers of nonoxynol-9 and their characterization by 1H-NMR and mass spectroscopy.
作者信息
Black D B, Dawson B A, Ethier J C, Neville G A
机构信息
Bureau of Drug Research, Health and Welfare Canada, Ottawa, ON.
出版信息
J Pharm Biomed Anal. 1990;8(6):527-33. doi: 10.1016/0731-7085(90)80063-u.
Conditions are described for the preparative LC separation of a bulk nonoxynol-9 material into 16 components. 1H-NMR analyses of these fractions provided evidence for all but the first of the components to be oligomers of nonylphenoxypolyethoxyethanol (nonoxynol) with n-values for (OCH2CH2)n ranging consecutively from 3 to 17, corresponding to the LC fractions 2-16. Mass spectral analysis of the separated LC fractions confirmed the oligomeric sizes deduced from 1H-NMR spectral data, and provided EI fragmentation information for these oligomeric substances.
描述了将大量壬苯醇醚-9 原料制备液相色谱分离为 16 种组分的条件。对这些馏分的 1H-NMR 分析提供了证据，表明除第一种组分外，所有组分都是壬基苯氧基聚乙氧基乙醇（壬苯醇醚）的低聚物，(OCH2CH2)n 的 n 值从 3 到 17 连续变化，对应于液相色谱馏分 2 - 16。对分离出的液相色谱馏分进行质谱分析，证实了从 1H-NMR 光谱数据推导的低聚物大小，并提供了这些低聚物质的电子轰击碎裂信息。
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