Department of Internal Medicine, Jewish General Hospital, McGill University, 3755 Cote St. Catherine Road, Montreal, Quebec, Canada H3T 1E2.
Int J Infect Dis. 2010 May;14(5):e433-5. doi: 10.1016/j.ijid.2009.05.012. Epub 2009 Aug 4.
The incidence of invasive aspergillosis is increasing due to more frequent use of immunosuppressant agents in patients with autoimmune diseases, hematological malignancies, and solid organ and hematopoietic stem cell transplants. Invasive aspergillosis most commonly affects the lungs, sinuses, and brain. Aspergillosis affecting the musculoskeletal system is rare. We describe here a case of articular aspergillosis in a febrile neutropenic patient successfully treated with voriconazole and caspofungin, and briefly review the 10 cases of articular aspergillosis that have previously been described in the literature.
由于自身免疫性疾病、血液系统恶性肿瘤、实体器官和造血干细胞移植患者中免疫抑制剂的使用越来越频繁，侵袭性曲霉菌病的发病率正在上升。侵袭性曲霉菌病最常影响肺部、鼻窦和大脑。影响肌肉骨骼系统的曲霉菌病很少见。我们在此描述了一例发热性中性粒细胞减少症患者的关节曲霉菌病，该患者成功地接受了伏立康唑和卡泊芬净治疗，并简要回顾了文献中以前描述的 10 例关节曲霉菌病。
