Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Mod Rheumatol. 2009;19(6):687-90. doi: 10.1007/s10165-009-0208-7. Epub 2009 Aug 6.
Osteopetrosis is an inherited disorder characterized by reduced bone resorption. We here report a rare case of osteopetrosis associated with rheumatoid arthritis. The patient was diagnosed as autosomal dominant osteopetrosis type II in his youth and developed rheumatoid arthritis at 42 years of age. In spite of the severe inflammation and rapid progression of cartilage destruction, the progression of bone erosion was slow in this patient.
骨质硬化症是一种遗传性疾病，其特征为骨吸收减少。我们在此报告一例罕见的骨质硬化症合并类风湿关节炎病例。该患者年轻时被诊断为常染色体显性遗传型Ⅱ型骨质硬化症，42 岁时发展为类风湿关节炎。尽管炎症严重且软骨破坏迅速进展，但该患者的骨侵蚀进展缓慢。
