Department of Orthopaedic Surgery, Washington University, St. Louis, Missouri 63110, USA.
J Orthop Res. 2010 Feb;28(2):241-7. doi: 10.1002/jor.20965.
Low-amplitude, whole-body vibration (WBV) may be anabolic for bone. Animal studies of WBV have not evaluated skeletal effects in aged animals. We exposed 75 male BALB/c mice (7 month/young-adult; 22 month/aged) to 5 weeks of daily WBV (15 min/day, 5 day/wk; 90 Hz sine wave) at acceleration amplitudes of 0 (sham), 0.3, or 1.0 g. Whole-body bone mineral content (BMC) increased with time in 7 month (p < 0.001) but not 22 month (p = 0.34) mice, independent of WBV (p = 0.60). In 7 month mice, lower-leg BMC increased with time in 0.3 and 1.0 g groups (p < 0.005) but not in the sham group (p = 0.09), indicating a positive WBV effect. In 22 month mice, there were no changes with time in lower-leg BMC (p = 0.11). WBV did not affect tibial trabecular or cortical bone structure (by microCT), dynamic indices of trabecular or cortical bone formation, trabecular osteoclast surface, or the mass of the reproductive fat pad (p > 0.05). Each of these outcomes was diminished in 7 month versus 22 month animals (p < 0.05). In summary, 5 weeks of daily exposure to low-amplitude WBV had no skeletal effects in aged male mice. The potential of WBV to enhance bone mass in age-related osteoporosis is not supported in this preclinical study.
低强度全身振动（WBV）可能对骨骼具有合成代谢作用。动物研究并未评估过年龄较大动物的骨骼影响。我们将 75 只雄性 BALB/c 小鼠（7 月龄/年轻成年；22 月龄/老年）暴露于 5 周的每日 WBV（15 分钟/天，每周 5 天；90 Hz 正弦波），加速度幅度分别为 0（假）、0.3 或 1.0 g。7 月龄（p < 0.001）而非 22 月龄（p = 0.34）小鼠的全身骨矿物质含量（BMC）随时间增加，与 WBV 无关（p = 0.60）。在 7 月龄小鼠中，0.3 和 1.0 g 组的小腿 BMC 随时间增加（p < 0.005），而假组则没有（p = 0.09），表明存在积极的 WBV 效应。在 22 月龄小鼠中，小腿 BMC 随时间没有变化（p = 0.11）。WBV 并未影响胫骨小梁或皮质骨结构（通过 microCT）、小梁或皮质骨形成的动态指数、小梁破骨细胞表面或生殖脂肪垫的质量（p > 0.05）。这些结果在 7 月龄与 22 月龄动物之间均有所降低（p < 0.05）。总之，5 周每日暴露于低强度 WBV 对老年雄性小鼠的骨骼没有影响。在这项临床前研究中，WBV 增强与年龄相关的骨质疏松症中骨量的潜力并未得到支持。
