Bakker-Woudenberg I A, Lokerse A F, ten Kate M
Department of Clinical Microbiology, Erasmus University Rotterdam, The Netherlands.
Scand J Infect Dis Suppl. 1990;74:54-7.
The antiviral effect of ganciclovir and foscarnet encapsulated in liposomes was studied against cytomegalovirus in human embryonic lung fibroblast cells. Substantially greater activity (3.5-fold and 38-fold respectively) in terms of inhibition of virus replication intracellularly was found compared to that seen with non-encapsulated antiviral agents, and liposome encapsulation did not result in increased cytotoxicity.
研究了脂质体包裹的更昔洛韦和膦甲酸钠对人胚肺成纤维细胞中巨细胞病毒的抗病毒作用。与未包裹的抗病毒药物相比，在细胞内抑制病毒复制方面发现活性显著更高（分别为3.5倍和38倍），且脂质体包裹并未导致细胞毒性增加。
