更昔洛韦与膦甲酸钠对巨细胞病毒体外复制的协同作用。
Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.
作者信息
Manischewitz J F, Quinnan G V, Lane H C, Wittek A E
机构信息
Laboratory of Herpesvirus Research, Food and Drug Administration, Bethesda, Maryland 20892.
出版信息
Antimicrob Agents Chemother. 1990 Feb;34(2):373-5. doi: 10.1128/AAC.34.2.373.
Abstract
Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity.
摘要
更昔洛韦和膦甲酸对巨细胞病毒具有显著活性。两者都表现出剂量限制性毒性，这降低了它们的临床实用性。我们证明了更昔洛韦和膦甲酸在体外对巨细胞病毒复制具有协同抑制作用。降低剂量的联合疗法可能提供一种治疗巨细胞病毒感染患者的方法，同时降低药物毒性。
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