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1
Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.更昔洛韦与膦甲酸钠对巨细胞病毒体外复制的协同作用。
Antimicrob Agents Chemother. 1990 Feb;34(2):373-5. doi: 10.1128/AAC.34.2.373.
2
Increased efficacy of ganciclovir and foscarnet inhibition of cytomegalovirus replication in vitro by encapsulation in liposomes.通过脂质体包封提高更昔洛韦和膦甲酸钠在体外抑制巨细胞病毒复制的效力。
Scand J Infect Dis Suppl. 1990;74:54-7.
3
Increased efficacy of ganciclovir in combination with foscarnet against cytomegalovirus and herpes simplex virus type 2 in vitro and in vivo.更昔洛韦与膦甲酸钠联合使用在体外和体内对巨细胞病毒和2型单纯疱疹病毒的疗效增强。
Antiviral Res. 1989 Nov;12(4):205-12. doi: 10.1016/0166-3542(89)90030-2.
4
Cytomegalovirus isolate resistant to ganciclovir and foscarnet from a marrow transplant patient.
Lancet. 1991 May 25;337(8752):1292-3. doi: 10.1016/0140-6736(91)92965-5.
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Foscarnet therapy for ganciclovir-resistant cytomegalovirus retinitis in patients with AIDS.膦甲酸钠治疗艾滋病患者中对更昔洛韦耐药的巨细胞病毒性视网膜炎
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Relevance of clinical and laboratory findings in the diagnosis of cytomegalovirus encephalitis in patients with AIDS.
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Report of a case of aggressive cytomegalovirus retinitis in an infant with AIDS.一例患艾滋病婴儿发生侵袭性巨细胞病毒性视网膜炎的病例报告。
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Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites.核酸衍生物拮抗剂。VIII. 生物化学相关抗代谢物组合中的协同作用。
J Biol Chem. 1954 Jun;208(2):477-88.
2
Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on human cytomegalovirus replication in vitro.9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤对人巨细胞病毒体外复制的影响。
Antimicrob Agents Chemother. 1983 Oct;24(4):518-21. doi: 10.1128/AAC.24.4.518.
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Treatment of cytomegalovirus pneumonia with high-dose acyclovir.大剂量阿昔洛韦治疗巨细胞病毒肺炎
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Cytomegalovirus disease in renal allograft recipients: a prospective study of the clinical features, risk factors and impact on renal transplantation.肾移植受者的巨细胞病毒病：一项关于临床特征、危险因素及对肾移植影响的前瞻性研究
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Infectious complications of the acquired immune deficiency syndrome.获得性免疫缺陷综合征的感染性并发症
Ann N Y Acad Sci. 1984;437:383-93. doi: 10.1111/j.1749-6632.1984.tb37158.x.
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Effect of adenine arabinoside on cytomegalovirus infections.阿糖腺苷对巨细胞病毒感染的影响。
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7
Treatment of cytomegalovirus pneumonitis with foscarnet (trisodium phosphonoformate) in patients with AIDS.用膦甲酸钠（三钠膦酰甲酸盐）治疗艾滋病患者的巨细胞病毒性肺炎。
J Med Virol. 1987 Jun;22(2):157-62. doi: 10.1002/jmv.1890220206.
8
Pharmacokinetics, safety and preliminary clinical experiences using foscarnet in the treatment of cytomegalovirus infections in bone marrow and renal transplant recipients.膦甲酸钠用于治疗骨髓和肾移植受者巨细胞病毒感染的药代动力学、安全性及初步临床经验
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Risk factors for cytomegalovirus infection after human marrow transplantation.人类骨髓移植后巨细胞病毒感染的危险因素。
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Effect of 9-(1,3-dihydroxy-2-propoxymethyl) guanine on serious cytomegalovirus disease in eight immunosuppressed homosexual men.
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更昔洛韦与膦甲酸钠对巨细胞病毒体外复制的协同作用。

Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.

作者信息

Manischewitz J F, Quinnan G V, Lane H C, Wittek A E

机构信息

Laboratory of Herpesvirus Research, Food and Drug Administration, Bethesda, Maryland 20892.

出版信息

Antimicrob Agents Chemother. 1990 Feb;34(2):373-5. doi: 10.1128/AAC.34.2.373.

DOI:10.1128/AAC.34.2.373
PMID:2158278
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171593/
Abstract

Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity.

摘要

更昔洛韦和膦甲酸对巨细胞病毒具有显著活性。两者都表现出剂量限制性毒性，这降低了它们的临床实用性。我们证明了更昔洛韦和膦甲酸在体外对巨细胞病毒复制具有协同抑制作用。降低剂量的联合疗法可能提供一种治疗巨细胞病毒感染患者的方法，同时降低药物毒性。