Victor Babes National Institute of Pathology, Bucharest, Romania.
J Cell Mol Med. 2009 Sep;13(9A):2949-51. doi: 10.1111/j.1582-4934.2009.00869.x. Epub 2009 Jul 29.
The human sub-epicardial area contains an unexplored cellular population under a layer of mesothelial cells. Transmission electron microscopy revealed the existence of interstitial Cajal-like cells (ICLCs), isolated smooth muscle cells (iSMC) and mesenchymal cells besides other well-known cells. The presence of iSMC in the sub-epicardial space is quite unique and could explain why epicardial-derived cells isolated from human epicardium generate smooth muscle cells in culture. Mesenchymal cells, guided by ICLCs, were found migrating from sub-epicardial area in the mesothelial layer. These findings suggest that epithelial-mesenchymal transition is not a common process involved in cardiac regeneration in vivo.
人类心外膜下区域的间皮细胞层下包含一个尚未被探索的细胞群体。透射电子显微镜显示，除了其他已知的细胞外，还存在间质 Cajal 样细胞（ICLCs）、孤立的平滑肌细胞（iSMC）和间充质细胞。心外膜下腔中存在 iSMC 是非常独特的，这可以解释为什么从人心外膜分离的心外膜衍生细胞在培养中会产生平滑肌细胞。在 ICLCs 的引导下，间充质细胞被发现从间皮层的心外膜下区域迁移。这些发现表明上皮-间充质转化不是体内心脏再生中常见的过程。
