Bhagavathula Narasimharao, Warner Roscoe L, DaSilva Marissa, McClintock Shannon D, Barron Adam, Aslam Muhammad N, Johnson Kent J, Varani James
Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Wound Repair Regen. 2009 May-Jun;17(3):360-6. doi: 10.1111/j.1524-475X.2009.00483.x.
Hairless rats were topically treated with a combination of 10% curcumin and 3% ginger extract (or with each agent alone) for a 21-day period. Following this, the rats were treated topically with Temovate (corticosteroid) for an additional 15 days. At the end of the treatment period, superficial abrasion wounds were induced in the treated skin. Abrasion wounds healed more slowly in the skin of Temovate-treated rats than in skin of control animals. Healing was more rapid in skin of rats that had been pretreated with either curcumin or ginger extract alone or with the combination of curcumin-ginger extract (along with Temovate) than in the skin of rats treated with Temovate and vehicle alone. Skin samples were obtained at the time of wound closure. Collagen production was increased and matrix metalloproteinase-9 production was decreased in the recently healed skin from rats treated with the botanical preparation relative to rats treated with Temovate plus vehicle. In none of the rats was there any indication of skin irritation during the treatment phase or during wounding and repair. Taken together, these data suggest that a combination of curcumin and ginger extract might provide a novel approach to improving structure and function in skin and, concomitantly, reducing formation of nonhealing wounds in "at-risk" skin.
将无毛大鼠局部用10%姜黄素和3%生姜提取物的组合（或单独使用每种药剂）处理21天。在此之后，大鼠再局部用特美肤（皮质类固醇）处理15天。在治疗期结束时，在处理过的皮肤上诱导形成浅表擦伤伤口。特美肤处理的大鼠皮肤中的擦伤伤口愈合比对照动物的皮肤慢。单独用姜黄素或生姜提取物预处理或用姜黄素 - 生姜提取物组合（连同特美肤）预处理的大鼠皮肤愈合比仅用特美肤和赋形剂处理的大鼠皮肤更快。在伤口闭合时获取皮肤样本。相对于用特美肤加赋形剂处理的大鼠，用植物制剂处理的大鼠新近愈合皮肤中的胶原蛋白生成增加且基质金属蛋白酶 - 9生成减少。在治疗阶段或伤口形成及修复期间，没有一只大鼠出现皮肤刺激迹象。综合来看，这些数据表明姜黄素和生姜提取物的组合可能为改善皮肤结构和功能以及同时减少“高危”皮肤中不愈合伤口的形成提供一种新方法。
