十二指肠碱化会释放促胰液素和血管活性肠肽，并刺激麻醉大鼠的胰腺外分泌。

Duodenal alkalinization releases secretin and vasoactive intestinal polypeptide and stimulates exocrine pancreatic secretion in the anesthetized rat.

作者信息

García L J, Minguela A, Montero A, Calvo J J, López M A

机构信息

Department of Physiology and Pharmacology, Faculty of Biology, University of Salamanca, Spain.

出版信息

Digestion. 1990;47(4):215-25. doi: 10.1159/000200500.

DOI:10.1159/000200500

PMID:1966046

Abstract

The effect of various intraduodenal alkaline solutions (0.1 M NaHCO3, 0.1 M Na2CO3 and 0.025 M NaOH) on exocrine pancreatic secretion and the release of two peptides, secretin and vasoactive intestinal polypeptide, was studied in anesthetized rats. The flow rate of the pancreatic juice was stimulated up to a maximum of 179, 158 and 180% and the protein output up to 181, 131 and 162% (compared with basal) after duodenal perfusion of, respectively, 0.1 M NaHCO3, 0.1 M Na2CO3 and 0.025 M NaOH. Maximum increases in portal plasma secretin concentrations of 143, 146 and 190% and maximum increases in VIP of 116, 155 and 147% after, respectively, intraduodenal 0.1 M NaHCO3, 0.1 M Na2CO3, and 0.025 M NaOH were found. In conclusion duodenal alkalinization in the rat produces a pancreatic exocrine secretory response that may be partially ascribed to the effect of secretin and VIP.

摘要

在麻醉大鼠中研究了各种十二指肠内碱性溶液（0.1M碳酸氢钠、0.1M碳酸钠和0.025M氢氧化钠）对胰腺外分泌以及两种肽（促胰液素和血管活性肠肽）释放的影响。分别用0.1M碳酸氢钠、0.1M碳酸钠和0.025M氢氧化钠进行十二指肠灌注后，胰液流速的最大刺激幅度分别达到基础值的179%、158%和180%，蛋白质输出量的最大刺激幅度分别达到基础值的181%、131%和162%。十二指肠内给予0.1M碳酸氢钠、0.1M碳酸钠和0.025M氢氧化钠后，门静脉血浆促胰液素浓度的最大增幅分别为143%、146%和190%，血管活性肠肽的最大增幅分别为116%、155%和147%。总之，大鼠十二指肠碱化会产生胰腺外分泌反应，这可能部分归因于促胰液素和血管活性肠肽的作用。