García L J, Calvo J J, Minguela A, López M A
Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain.
Rev Esp Fisiol. 1992 Dec;48(4):285-9.
The effect of intraduodenal sodium bicarbonate, 0.1 M, on exocrine pancreatic secretion and the release of two peptides, secretin and VIP, was studied in anesthetized rats and rabbits, two species largely used in the gastroenterology laboratories. In the rabbit, intraduodenal sodium bicarbonate perfusion had no effect either on exocrine pancreatic secretion or on portal plasma levels of secretin and VIP. By contrast, in the rat, intraduodenal sodium bicarbonate perfusion significantly increased hydroelectrolyte exocrine pancreatic secretion and portal plasma secretin levels. A clear interspecific difference reflecting the different gastrointestinal physiology of both species is observed.
在麻醉的大鼠和兔子（这两种在胃肠病学实验室中大量使用的物种）身上，研究了0.1M十二指肠内碳酸氢钠对胰腺外分泌和两种肽（促胰液素和血管活性肠肽）释放的影响。在兔子身上，十二指肠内灌注碳酸氢钠对胰腺外分泌或门静脉血浆中促胰液素和血管活性肠肽的水平均无影响。相比之下，在大鼠身上，十二指肠内灌注碳酸氢钠显著增加了胰腺外分泌的水电解质分泌和门静脉血浆促胰液素水平。观察到了一个明显的种间差异，反映了这两个物种不同的胃肠生理学特征。
