Medical School, University of Tampere, 33014 Tampere, Finland.
Psychoneuroendocrinology. 2009 Dec;34 Suppl 1:S278-86. doi: 10.1016/j.psyneuen.2009.07.003.
This is a mini-review of vitamin D(3), its active metabolites and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vitamin D(3) endocrine system consists of 3 active calcipherol hormones: calcidiol (25OHD(3)), 1alpha-calcitriol (1alpha,25(OH)2D(3)) and 24-calcitriol (24,25(OH)2D(3)). The impact of the calcipherol hormone system on aging, health and disease is discussed. Low serum calcidiol concentrations are associated with an increased risk of several chronic diseases including osteoporosis, cancer, diabetes, autoimmune disorders, hypertension, atherosclerosis and muscle weakness all of which can be considered aging-related diseases. The relationship of many of these diseases and aging-related changes in physiology show a U-shaped response curve to serum calcidiol concentrations. Clinical data suggest that vitamin D(3) insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimer's and Parkinson's disease, seasonal affective disorder and schizophrenia. In line with this, recent animal and human studies suggest that vitamin D insufficiency is associated with abnormal development and functioning of the CNS. Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS.
这是一篇关于维生素 D(3)、其活性代谢物及其在中枢神经系统 (CNS) 中的功能的综述，特别是与神经系统疾病和衰老的关系。维生素 D(3)内分泌系统由 3 种活性钙醇激素组成：25-羟维生素 D(3)（calcidiol，25OHD(3)）、1α-羟维生素 D(3)（1α,25(OH)2D(3)）和 24,25-二羟维生素 D(3)（24,25(OH)2D(3)）。本文讨论了钙醇激素系统对衰老、健康和疾病的影响。血清 25-羟维生素 D(3)浓度降低与多种慢性疾病的风险增加有关，包括骨质疏松症、癌症、糖尿病、自身免疫性疾病、高血压、动脉粥样硬化和肌肉无力，所有这些都可以被认为与衰老有关的疾病。这些疾病和与衰老相关的生理变化之间的许多关系呈现出血清 25-羟维生素 D(3)浓度的 U 型反应曲线。临床数据表明，维生素 D(3)不足与多种中枢神经系统疾病的风险增加有关，包括多发性硬化症、阿尔茨海默病和帕金森病、季节性情感障碍和精神分裂症。与此一致，最近的动物和人类研究表明，维生素 D(3)不足与中枢神经系统的异常发育和功能有关。总的来说，钙醇系统的失衡似乎导致了中枢神经系统的异常功能，包括过早衰老。
