Endocrinology Diabetology and Andrology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.
Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.
Front Endocrinol (Lausanne). 2023 Aug 24;14:1231580. doi: 10.3389/fendo.2023.1231580. eCollection 2023.
Osteoporosis (OP) and Dermatoporosis (DP) are expressions of the aging process at the skin and bone levels, respectively. Both conditions are associated with increased morbidity for elderly people, and this requires necessary interventions. They share many common risk factors; among these, vitamin D (VD) deficiency appears to have a role. VD is involved in either disease with many mechanisms, among which immunomodulation. VD deficiency has been linked to OP because it inhibits the body's capacity to absorb calcium and maintain optimal bone health. Available evidence suggests that proper vitaminosis D also appears to be vital in preventing skin age-related issues. DP is often seen in elderly individuals, particularly those with long-term sun exposure and a history of chronic sun damage. VD deficiency can be linked to DP, since its involvement in collagen production, epidermal barrier function, inflammation regulation, wound healing, and sun protection. Aim of this review is to summarize the most updated existing evidence on the role of VD in the development of fragility syndromes such as DP and OP and the possible benefits of VD supplementation as a simple and harmful weapon against aging.
骨质疏松症（OP）和皮肤疏松症（DP）分别是皮肤和骨骼衰老过程的表现。这两种情况都与老年人的发病率增加有关，因此需要进行必要的干预。它们有许多共同的危险因素；其中，维生素 D（VD）缺乏似乎起作用。VD 参与这两种疾病，有许多机制，包括免疫调节。VD 缺乏与 OP 有关，因为它抑制了身体吸收钙和维持最佳骨骼健康的能力。现有证据表明，适当的维生素 D 缺乏症似乎对预防与皮肤相关的衰老问题也至关重要。DP 常见于老年人，特别是那些长期暴露在阳光下且有慢性太阳损伤史的人。VD 缺乏与 DP 有关，因为它参与胶原蛋白的产生、表皮屏障功能、炎症调节、伤口愈合和防晒。本综述的目的是总结 VD 在 DP 和 OP 等脆弱综合征发展中的作用的最新现有证据，以及 VD 补充作为一种简单而无害的对抗衰老的武器的可能益处。
