Yowell R, Hammond E
LDS Hospital Electron Microscopy Laboratory, University of Utah, Salt Lake City 84143.
Ultrastruct Pathol. 1992 Jan-Apr;16(1-2):11-6. doi: 10.3109/01913129209074544.
A case of Ki-1 lymphoma of the large cell anaplastic type with weak leukocyte common antigen expression is presented. These tumors can sometimes demonstrate confusing immunophenotypes (weak or negative leukocyte common antigen, pan T, pan B, HMB 45, and S-100, and anomalous positive epithelial membrane antigen staining), and ultrastructural examination may be requested. The tumor consisted of sheets of large malignant cells with large pleomorphic nuclei, prominent nucleoli, and a high mitotic rate. Ultrastructural examination showed pleomorphic tumor cells with irregular nuclei, large nucleoli, and abundant complex cytoplasm with varied organelles.
本文报告一例大细胞间变性Ki-1淋巴瘤，白细胞共同抗原表达较弱。这些肿瘤有时可表现出令人困惑的免疫表型（白细胞共同抗原弱表达或阴性、全T、全B、HMB 45和S-100，以及异常阳性的上皮膜抗原染色），可能需要进行超微结构检查。肿瘤由大片大的恶性细胞组成，细胞核大且多形性，核仁突出，有丝分裂率高。超微结构检查显示多形性肿瘤细胞，细胞核不规则，核仁大，细胞质丰富且复杂，细胞器多样。
