一项关于硫酸洛贝林戒烟的多中心3期试验。
A multicenter phase 3 trial of lobeline sulfate for smoking cessation.
作者信息
Glover Elbert D, Rath Jessica M, Sharma Eva, Glover Penny N, Laflin Molly, Tonnesen Philip, Repsher Lawrence, Quiring John
机构信息
Department of Public and Community Health, Center for Health Behavior Research, University of Maryland, College Park School of Public Health, College Park, MD
出版信息
Am J Health Behav. 2010 Jan-Feb;34(1):101-9. doi: 10.5993/ajhb.34.1.12.
OBJECTIVE
To evaluate the safety and efficacy of sublingual lobeline sulfate for smoking cessation.
METHODS
A multicenter (3 sites), double-blind, parallel, placebo-controlled, phase 3 smoking cessation trial of sublingual formulation of lobeline sulfate. A total of 750 smokers (250 per site) were randomized to either treatment (lobeline sulfate) or placebo with individual smoking cessation counseling lasting up to approximately 10 minutes.
RESULTS
Efficacy revealed no statistical significance (P = 0.62) for lobeline sulfate as a smoking cessation aid.
CONCLUSION
Sublingual formulation of lobeline sulfate does not appear to be an effective smoking cessation aid.
目的
评估硫酸洛贝林舌下含片戒烟的安全性和有效性。
方法
一项多中心（3个地点）、双盲、平行、安慰剂对照的硫酸洛贝林舌下含片3期戒烟试验。总共750名吸烟者（每个地点250名）被随机分为治疗组（硫酸洛贝林）或安慰剂组，并接受长达约10分钟的个人戒烟咨询。
结果
作为戒烟辅助药物，硫酸洛贝林的疗效无统计学意义（P = 0.62）。
结论
硫酸洛贝林舌下含片似乎不是一种有效的戒烟辅助药物。
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