Kupczyk Piotr, Reich Adam, Szepietowski Jacek C
Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
Exp Dermatol. 2009 Aug;18(8):669-79. doi: 10.1111/j.1600-0625.2009.00923.x.
Cannabinoids and their derivatives are group of more than 60 biologically active chemical agents, which have been used in natural medicine for centuries. The major agent of exogenous cannabinoids is Delta(9)-tetrahydrocannabinol (Delta(9)-THC), natural psychoactive ingredient of marijuana. However, psychoactive properties of these substances limited their use as approved medicines. Recent discoveries of endogenous cannabinoids (e.g. arachidonoylethanolamide, 2-arachidonoylglycerol or palmithyloethanolamide) and their receptors initiated discussion on the role of cannabinoid system in physiological conditions as well as in various diseases. Based on the current knowledge, it could be stated that cannabinoids are important mediators in the skin, however their role have not been well elucidated yet. In our review, we summarized the current knowledge about the significant role of the cannabinoid system in the cutaneous physiology and pathology, pointing out possible future therapeutic targets.
大麻素及其衍生物是一组60多种具有生物活性的化学物质，几个世纪以来一直在天然药物中使用。外源性大麻素的主要成分是Δ⁹-四氢大麻酚（Δ⁹-THC），即大麻的天然精神活性成分。然而，这些物质的精神活性特性限制了它们作为获批药物的使用。内源性大麻素（如花生四烯酸乙醇胺、2-花生四烯酸甘油或棕榈酰乙醇胺）及其受体的最新发现引发了关于大麻素系统在生理状况以及各种疾病中作用的讨论。基于目前的知识，可以说大麻素是皮肤中的重要介质，但其作用尚未得到充分阐明。在我们的综述中，我们总结了关于大麻素系统在皮肤生理和病理中的重要作用的当前知识，指出了未来可能的治疗靶点。
