关节软骨干细胞信号传导
Articular cartilage stem cell signalling.
作者信息
Karlsson Camilla, Lindahl Anders
出版信息
Arthritis Res Ther. 2009;11(4):121. doi: 10.1186/ar2753. Epub 2009 Jul 24.
Abstract
The view of articular cartilage as a non-regeneration organ has been challenged in recent years. The articular cartilage consists of distinct zones with different cellular and molecular phenotypes, and the superficial zone has been hypothesized to harbour stem cells. Furthermore, the articular cartilage demonstrates a distinct pattern regarding stem cell markers (that is, Notch-1, Stro-1, and vascular cell adhesion molecule-1). These results, in combination with the positive identification of side population cells in articular cartilage, give additional support for the hypothesis that articular cartilage has residing stem cells with a potential regenerative capacity where the controlling mechanism could be future biomarkers or drug targets or both.
摘要
近年来，关节软骨作为一种无再生能力器官的观点受到了挑战。关节软骨由具有不同细胞和分子表型的不同区域组成，并且有人推测表层区域含有干细胞。此外，关节软骨在干细胞标志物（即Notch-1、Stro-1和血管细胞粘附分子-1）方面表现出独特的模式。这些结果，再加上在关节软骨中对侧群细胞的阳性鉴定，为关节软骨中存在具有潜在再生能力的驻留干细胞这一假说提供了更多支持，其中控制机制可能是未来的生物标志物或药物靶点，或者两者皆是。
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