神经嵴源性干细胞和鼻软骨细胞对关节软骨再生的贡献。
Contribution of neural crest-derived stem cells and nasal chondrocytes to articular cartilage regeneration.
机构信息
Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, 64 Medical Center Drive, PO Box 9196, Morgantown, WV, 26506-9196, USA.
Department of Pediatric Orthopaedics, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
出版信息
Cell Mol Life Sci. 2020 Dec;77(23):4847-4859. doi: 10.1007/s00018-020-03567-y. Epub 2020 Jun 5.
Abstract
Due to poor self-regenerative potential of articular cartilage, stem cell-based regeneration becomes a hopeful approach for the treatment of articular cartilage defects. Recent studies indicate that neural crest-derived cells (NCDCs) have the potential for repairing articular cartilage with even greater chondrogenic capacity than mesoderm-derived cells (MDCs): a conventional stem cell source for cartilage regeneration. Given that NCDCs originate from a different germ layer in the early embryo compared with MDCs that give rise to articular cartilage, a mystery remains regarding their capacity for articular cartilage regeneration. In this review, we summarize the similarities and differences between MDCs and NCDCs including articular and nasal chondrocytes in cell origin, anatomy, and chondrogenic differentiation and propose that NCDCs might be promising cell origins for articular cartilage regeneration.
摘要
由于关节软骨自我再生能力差，基于干细胞的再生成为治疗关节软骨缺损的一种有希望的方法。最近的研究表明，神经嵴源性细胞（NCDC）具有修复关节软骨的潜力，其软骨生成能力甚至比中胚层源性细胞（MDC）更大：MDC 是软骨再生的传统干细胞来源。鉴于 NCDC 起源于胚胎早期的不同胚层，而 MDC 则产生关节软骨，因此，它们在关节软骨再生方面的能力仍然是一个谜。在这篇综述中，我们总结了 MDC 和 NCDC 之间的相似性和差异，包括细胞起源、解剖结构和软骨分化的关节和鼻软骨细胞，并提出 NCDC 可能是关节软骨再生有前途的细胞来源。
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