Kadkhodayan Yasha, Moran Christopher J, Derdeyn Colin P, Cross DeWitte T
Interventional Neuroradiology, Mallinckrodt Institute of Radiology, St. Louis, MO 63110, USA.
Surg Neurol. 2009 Nov;72(5):451-5; discussion 455. doi: 10.1016/j.surneu.2009.05.017. Epub 2009 Aug 7.
Conventional treatment of stenosis at the common carotid artery origin has involved extra-anatomic bypass using an open cervical approach or median sternotomy. The goal of this study is to determine the procedural feasibility and safety of angioplasty and stenting at the common carotid origin as a less invasive alternative.
Between March 1996 and November 2005, a total of 248 carotid angioplasty and/or stenting procedures were performed at our institution. Of these, 8 procedures were performed in 7 patients for treatment of a stenosis or dissection located at the common carotid origin. There were 4 males and 3 females with a mean age of 58 (range, 22-77). Five patients presented with neurologic symptoms. The patients' medical records were retrospectively reviewed for imaging reports (cerebral angiography, computed tomography, or ultrasound) and available clinical follow-up. Brief telephone interviews with patients, immediate family, or care personnel were also used. Procedural and midterm complication rates were calculated.
Of 8 procedures, 7 (87.5%) resulted in no residual stenosis. The procedural stroke rate was 0 (0%) of 8 procedures. The procedural TIA rate was 2 (25%) of 8 procedures. The mean follow-up was 31.7 months (range, 11.3-75.9 months). In 2 cases, follow-up was clinical only. In the remaining cases, there were clinical and imaging follow-up in the form of cerebral angiography (n = 3), CT angiography (n = 2), and ultrasound (n = 1). There was one recurrent TIA at 30 days and again at 3.1 months (1/8, 12.5%). There were no strokes (0/8, 0%) and there were no TIAs in patients who were initially asymptomatic on presentation. There was one death from an unrelated cause.
In this series, angioplasty and stenting were effective in relieving stenosis at the common carotid origin and have low rates of ischemic complications.
颈总动脉起始部狭窄的传统治疗方法包括采用开放的颈部入路或正中胸骨切开术进行解剖外旁路手术。本研究的目的是确定颈总动脉起始部血管成形术和支架置入术作为一种侵入性较小的替代方法的手术可行性和安全性。
1996年3月至2005年11月期间,我们机构共进行了248例颈动脉血管成形术和/或支架置入术。其中,7例患者接受了8例手术,用于治疗颈总动脉起始部的狭窄或夹层。男性4例,女性3例,平均年龄58岁(范围22 - 77岁)。5例患者出现神经症状。对患者的病历进行回顾性审查,以获取影像学报告(脑血管造影、计算机断层扫描或超声)以及现有的临床随访资料。还对患者、直系亲属或护理人员进行了简短的电话访谈。计算手术和中期并发症发生率。
8例手术中,7例(87.5%)无残余狭窄。8例手术的手术卒中率为0(0%)。8例手术的手术短暂性脑缺血发作(TIA)率为2例(25%)。平均随访时间为31.7个月(范围11.3 - 75.9个月)。2例仅进行了临床随访。其余病例采用脑血管造影(n = 3)、CT血管造影(n = 2)和超声(n = 1)的形式进行临床和影像学随访。术后30天出现1次复发性TIA,3.1个月时再次出现(1/8,12.5%)。无卒中发生(0/8,0%),初始表现无症状的患者未出现TIA。有1例因无关原因死亡。
在本系列研究中,血管成形术和支架置入术可有效缓解颈总动脉起始部狭窄,缺血性并发症发生率较低。