Ozawa A, Ohnishi N, Aiba Y, Yamamoto T
Department of Microbiology, School of Medicine, Tokai University, Kanagawa, Japan.
Tokai J Exp Clin Med. 1990 May;15(2-3):111-21.
Our results indicate that the responsiveness of the phagocytic and intracellular killing process of peripheral blood granulocytes and peritoneal phagocytic cells in infected germfree mice is due primarily to the OCl- (hypochloride ion) with myeloperoxidase involvement, while the response in infected conventional mice is brought about mainly by the O2- (superoxide anion). These facts are believed to be invaluable footholds in elucidating the quantitative and qualitative differences in phagocytic cell response depending upon the presence or absence of intestinal flora.
我们的结果表明，无菌感染小鼠外周血粒细胞和腹腔吞噬细胞的吞噬及细胞内杀伤过程的反应性主要归因于髓过氧化物酶参与下的次氯酸根离子（OCl-），而常规感染小鼠的反应主要由超氧阴离子（O2-）引起。据信，这些事实对于阐明取决于肠道菌群存在与否的吞噬细胞反应在数量和质量上的差异具有重要的立足点。
