Ozawa A, Ohnishi N, Tazume S, Aiba Y, Watanabe K
Department of Microbiology, School of Medicine, Tokai University, Kanagawa, Japan.
Tokai J Exp Clin Med. 1986;11 Suppl:65-79.
The protective mechanisms of intestinal bacterial flora against exogenous infections will be discussed in this paper. Experimental data on protective function of Escherichia coli, Enterococcus faecalis and Bacteroides distasonis comprising intestinal flora against oral infection of Shigella flexneri which causes localized infection are presented. Furthermore, the present investigation deals with non-specific defense mechanism which indicate that protective activity of intestinal flora against parenteral infection of Salmonella typhimurium mainly depend upon the larger number of functional kupffer cells in conventional mice than in that of their germfree counterparts.
本文将讨论肠道菌群对外源性感染的保护机制。文中给出了有关构成肠道菌群的大肠杆菌、粪肠球菌和狄氏拟杆菌对引起局部感染的福氏志贺菌经口感染的保护功能的实验数据。此外，本研究还涉及非特异性防御机制，该机制表明肠道菌群对鼠伤寒沙门氏菌肠道外感染的保护活性主要取决于普通小鼠中功能性枯否细胞的数量多于无菌小鼠。
