[小檗胺的抗氧化作用]
[Antioxidant effect of berbamine].
作者信息
Ju H S, Han Z W
机构信息
Department of Pharmacology, Inner Mongolia Medical College, Huhehot, China.
出版信息
Zhongguo Yao Li Xue Bao. 1990 Nov;11(6):539-41.
The antiperoxidant action of berbamine (Ber) was demonstrated by colorimetric estimation of malondialdehyde (MDA) formation, and the scavenging effect of Ber on O2- was investigated by chemiluminescence method and ESR-spin trapping technique. Ber 11-100 mumol/L remarkably inhibited MDA formation induced by incubating mice liver homogenate at 37 degrees C with vibration for 1 h. Ber 1-100 mumol/L and 0.2-0.6 mmol/L effectively scavenged O2- in alkaline DMSO and xanthine/xanthine oxidase systems respectively. The results show that Ber is an antioxidant.
通过比色法测定丙二醛（MDA）的生成来证明小檗胺（Ber）的抗氧化作用，并采用化学发光法和电子自旋共振自旋捕集技术研究了Ber对超氧阴离子（O2-）的清除作用。11 - 100 μmol/L的Ber显著抑制了在37℃下将小鼠肝脏匀浆振动孵育1小时所诱导的MDA生成。1 - 100 μmol/L的Ber和0.2 - 0.6 mmol/L的Ber分别在碱性二甲基亚砜和黄嘌呤/黄嘌呤氧化酶系统中有效清除O2-。结果表明，Ber是一种抗氧化剂。
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