Ikeda Etsuko, Morita Ritsuko, Nakao Kazuhisa, Ishida Kentaro, Nakamura Takashi, Takano-Yamamoto Teruko, Ogawa Miho, Mizuno Mitsumasa, Kasugai Shohei, Tsuji Takashi
Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan.
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13475-80. doi: 10.1073/pnas.0902944106. Epub 2009 Aug 3.
Current approaches to the development of regenerative therapies have been influenced by our understanding of embryonic development, stem cell biology, and tissue engineering technology. The ultimate goal of regenerative therapy is to develop fully functioning bioengineered organs which work in cooperation with surrounding tissues to replace organs that were lost or damaged as a result of disease, injury, or aging. Here, we report a successful fully functioning tooth replacement in an adult mouse achieved through the transplantation of bioengineered tooth germ into the alveolar bone in the lost tooth region. We propose this technology as a model for future organ replacement therapies. The bioengineered tooth, which was erupted and occluded, had the correct tooth structure, hardness of mineralized tissues for mastication, and response to noxious stimulations such as mechanical stress and pain in cooperation with other oral and maxillofacial tissues. This study represents a substantial advance and emphasizes the potential for bioengineered organ replacement in future regenerative therapies.
目前再生疗法的发展方法受到我们对胚胎发育、干细胞生物学和组织工程技术的理解的影响。再生疗法的最终目标是开发功能完全正常的生物工程器官，这些器官与周围组织协同工作，以替代因疾病、损伤或衰老而丧失或受损的器官。在此，我们报告了通过将生物工程牙胚移植到缺失牙区域的牙槽骨中，在成年小鼠身上成功实现了功能完全正常的牙齿替换。我们提出这项技术可作为未来器官替代疗法的一个模型。萌出并咬合的生物工程牙齿具有正确的牙齿结构、用于咀嚼的矿化组织硬度，并且能与其他口腔颌面组织协同对机械应力和疼痛等有害刺激作出反应。这项研究代表了一项重大进展，并强调了生物工程器官替代在未来再生疗法中的潜力。
