Elliott-DeSorbo Deborah K, Martin Staci, Wolters Pamela L
Neuropsychology Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
J Acquir Immune Defic Syndr. 2009 Nov 1;52(3):364-70. doi: 10.1097/QAI.0b013e3181b73568.
To assess the relationship between number and type of stressful life events (SLEs) and psychological and medical functioning in HIV-infected children.
For this cross-sectional study, caregivers of 55 vertically infected children aged 8-17 years completed a measure assessing SLEs occurring in the past 6 months. Children and caregivers both completed a questionnaire assessing the child's level of depression and anxiety. Concurrent demographic and medical data were gathered from chart review.
School-related SLEs were the most common type of event and predicted child-reported depressive symptoms. Children who had disclosed their diagnosis in the past 6 months were rated as more anxious by their caregivers than nondisclosers. Also, disclosers had lower CD4 percentages and absolute counts and higher viral load levels and were more likely to have been hospitalized recently. The total number of loss-related SLEs predicted viral load levels. Finally, children who experienced at least 1 financially related SLE had lower CD4 counts and were more likely to have been hospitalized than those experiencing no financial SLEs. Overall, children and caregivers reported nonsignificant levels of child depression and anxiety.
Both the total number and type of SLEs experienced have important implications for psychological and medical functioning in HIV-infected youth.
评估应激性生活事件（SLEs）的数量和类型与感染HIV儿童心理及医学功能之间的关系。
在这项横断面研究中，55名年龄在8至17岁的垂直感染儿童的照料者完成了一项评估过去6个月内发生的SLEs的测量。儿童和照料者均完成了一份评估儿童抑郁和焦虑水平的问卷。同时从病历审查中收集人口统计学和医学数据。
与学校相关的SLEs是最常见的事件类型，并可预测儿童报告的抑郁症状。在过去6个月内披露其诊断的儿童被照料者评为比未披露者更焦虑。此外，披露者的CD4百分比和绝对计数较低，病毒载量水平较高，且最近更有可能住院。与损失相关的SLEs总数可预测病毒载量水平。最后，经历至少1次与经济相关的SLE的儿童CD4计数较低，且比未经历经济SLE的儿童更有可能住院。总体而言，儿童和照料者报告的儿童抑郁和焦虑水平无显著差异。
经历的SLEs的总数和类型对感染HIV青少年的心理及医学功能均具有重要影响。
