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银屑病最常见的光疗处方是什么:窄谱中波紫外线(NB-UVB)还是补骨脂素加长波紫外线(PUVA)?处方行为。

What is the most common phototherapy prescription for psoriasis: NB-UVB or PUVA? Prescription behavior.

作者信息

Duarte Ida, Cunha José Antonio Jabur da, Bedrikow Roberta Buense, Lazzarini Rosana

机构信息

Faculdade de Medicina da Santa Casa de São Paulo, Santa Casa de São Paulo, SP, Brazil.

出版信息

An Bras Dermatol. 2009 Jul;84(3):244-8. doi: 10.1590/s0365-05962009000300005.

Abstract

BACKGROUND

Moderate and severe forms of psoriasis require phototherapy and / or systemic medications. Both UVA and UVB can be used to treat cases of moderate and severe psoriasis, and the effectiveness of both has been proven.

OBJECTIVE

to access the prescription behavior relating to two types of phototherapy for treating psoriasis refractory to topical treatment: narrowband UVB (NB-UVB) or psoralen plus UVA phototherapy (PUVA).

METHODS

Between January 2006 and December 2007, patients referred to two phototherapy services were included in this study. Data on the cases and on the type of prescription were collected retrospectively.

RESULTS

Among the 67 studied patients, 51 (76%) were treated with narrowband UVB. The reasons for the indication were the presence of the guttate type of psoriasis (22%), the presence of thin plaques (15%), the use of drugs that affected photosensitivity (15%), age less than 20 years (9%), skin type I (9%), and liver disease (6%). The remaining 16 (24%) were treated with PUVA. The main indication for this therapy was the severity of the disease (15%), followed by the presence of skin type IV (9%).

CONCLUSIONS

Prescriptions of narrowband UVB exceeded those of PUVA because of fewer contraindications and fewer possible side effects, and because it was a more practical option.

摘要

背景

中度和重度银屑病需要光疗和/或全身用药。UVA和UVB均可用于治疗中度和重度银屑病,且二者的有效性均已得到证实。

目的

了解与两种治疗局部治疗无效的银屑病光疗方法相关的处方行为:窄谱中波紫外线(NB-UVB)或补骨脂素加UVA光疗(PUVA)。

方法

2006年1月至2007年12月期间,纳入转至两家光疗服务机构的患者。回顾性收集病例及处方类型的数据。

结果

在67例研究患者中,51例(76%)接受窄谱中波紫外线治疗。指征原因包括点滴状银屑病(22%)、薄斑块(15%)、使用影响光敏性的药物(15%)、年龄小于20岁(9%)、皮肤I型(9%)和肝病(6%)。其余16例(24%)接受PUVA治疗。该治疗的主要指征是疾病严重程度(15%),其次是皮肤IV型(9%)。

结论

窄谱中波紫外线的处方超过PUVA,原因是禁忌证和可能的副作用较少,且是更实用的选择。

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